The endothelial cells (ECs) make up the inner lining of blood vessels, acting as a barrier
separating the blood and the tissues in several organs. ECs maintain endothelium integrity …

Targeting angiogenesis has remained one of the important aspects in disease biology in
general and cancer in particular. Currently (June 2023), over 593 clinical trials have been …

Diabetic retinopathy (DR) is a leading cause of irreversible vision loss in working-age
populations. Fat mass and obesity-associated protein (FTO) is an N6-methyladenosine …

The major functions of the arterial system are to “efficiently deliver blood to the peripheral
organs and maintain vascular homeostasis”. Both the endothelial and medial layer …

Renal injury and the development of albuminuria are tightly connected with the loss of
podocytes. Podocyte damages cause proteinuric renal diseases since podocyte foot …

Diabetic vascular complications (DVCs), including macro-and micro-angiopathy, account for
a high percentage of mortality in patients with diabetes mellitus (DM). Endothelial …

Ethnopharmacological relevance Herba epimedium brevicornu maxim is traditionally known
as a sexual enhancement, and has the effect of tonifying kidney yang. Icariin is a flavonoid …

Penile erection is mediated by the corpora cavernosa, a trabecular-like vascular bed that
enlarges upon vasodilation, but its regulation is not completely understood. Here, we show …

Abstract Background Endothelial cells (ECs) and pericytes (PCs) are crucial components of
the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding …

Idiopathic pulmonary fibrosis (IPF) is a devastating fibrotic lung disease characterized by
scarring and destruction of the lung architecture, with limited treatment options. Targeted …