Epithelial barrier hypothesis: effect of the external exposome on the microbiome and epithelial barriers in allergic disease

Z Celebi Sozener, B Ozdel Ozturk, P Cerci, M Turk… - Allergy, 2022 - Wiley Online Library
Environmental exposure plays a major role in the development of allergic diseases. The
exposome can be classified into internal (eg, aging, hormones, and metabolic processes) …

Perinatal and early-life nutrition, epigenetics, and allergy

N Acevedo, B Alashkar Alhamwe, L Caraballo, M Ding… - Nutrients, 2021 - mdpi.com
Epidemiological studies have shown a dramatic increase in the incidence and the
prevalence of allergic diseases over the last several decades. Environmental triggers …

Role of histone post-translational modifications in inflammatory diseases

Y Lin, T Qiu, G Wei, Y Que, W Wang, Y Kong… - Frontiers in …, 2022 - frontiersin.org
Inflammation is a defensive reaction for external stimuli to the human body and generally
accompanied by immune responses, which is associated with multiple diseases such as …

The role of cigarette smoke-induced pulmonary vascular endothelial cell apoptosis in COPD

Q Song, P Chen, XM Liu - Respiratory Research, 2021 - Springer
Chronic obstructive pulmonary disease (COPD) is one of the most common chronic
respiratory diseases with high morbidity and mortality. It has become the fifth most burdened …

Omics technologies in allergy and asthma research: An EAACI position paper

U Radzikowska, K Baerenfaller, JA Cornejo‐Garcia… - Allergy, 2022 - Wiley Online Library
Allergic diseases and asthma are heterogenous chronic inflammatory conditions with
several distinct complex endotypes. Both environmental and genetic factors can influence …

The impact of milk and its components on epigenetic programming of immune function in early life and beyond: implications for allergy and asthma

BCAM Esch, M Porbahaie, S Abbring… - Frontiers in …, 2020 - frontiersin.org
Specific and adequate nutrition during pregnancy and early life is an important factor in
avoiding non-communicable diseases such as obesity, type 2 diabetes, cardiovascular …

Identification of extracellular vesicle microRNA signatures specifically linked to inflammatory and metabolic mechanisms in obesity‐associated low type‐2 asthma

F Alhamdan, T Greulich, C Daviaud, LM Marsh… - Allergy, 2023 - Wiley Online Library
Abstract Rationale and Objective Plasma extracellular vesicles (EVs) represent a vital
source of molecular information about health and disease states. Due to their heterogenous …

Short-chain fatty acids augment differentiation and function of human induced regulatory T cells

M Hu, B Alashkar Alhamwe, B Santner-Nanan… - International Journal of …, 2022 - mdpi.com
Regulatory T cells (Tregs) control immune system activity and inhibit inflammation. While, in
mice, short-chain fatty acids (SCFAs) are known to be essential regulators of naturally …

Extracellular vesicles and asthma—More than just a co-existence

B Alashkar Alhamwe, DP Potaczek, S Miethe… - International journal of …, 2021 - mdpi.com
Extracellular vesicles (EVs) are membranous structures, which are secreted by almost every
cell type analyzed so far. In addition to their importance for cell-cell communication under …

Epigenetic regulation of airway epithelium immune functions in asthma

B Alashkar Alhamwe, S Miethe… - Frontiers in …, 2020 - frontiersin.org
Asthma is a chronic inflammatory disease of the respiratory tract characterized by recurrent
breathing problems resulting from airway obstruction and hyperresponsiveness. Human …