Tuberculosis (TB) remains a leading cause of infectious death worldwide, and poverty is a
major driver. Clinically, TB presents as “latent” TB and active TB disease, and the treatment …

Therapeutic drug monitoring (TDM) plays an important role in ensuring optimal drug therapy
and has become increasingly important in clinical practice. In the first part of this review …

BACKGROUND: Optimal drug dosing is important to ensure adequate response to
treatment, prevent development of drug resistance and reduce drug toxicity. The aim of …

Purpose: In the present narrative review, the authors aimed to discuss the relationship
between the pharmacokinetic/pharmacodynamic (PK/PD) of antibiotics and clinical …

Successful tuberculosis (TB) therapy requires achieving sufficient exposure to multiple
drugs. Limited stability of several first-line anti-TB drugs might compromise reliable …

The rapid quantification of antimicrobial agents is important for therapeutic drug monitoring
(TDM), enabling personalized dosing schemes in critically ill patients. Highly sophisticated …

Aims Linezolid is often used for the infections caused by drug‐resistant Gram‐positive
bacteria. Recent studies suggest that large between‐subject variability (BSV) and within …

Objectives: Isoniazid is a key drug in the chemotherapy of tuberculosis (TB), however,
interindividual variability in pharmacokinetic parameters and drug plasma levels may affect …

BACKGROUND: The aim of these clinical standards is to provide guidance on 'best practice´
for diagnosis, treatment and management of drug-susceptible pulmonary TB (PTB) …

Standard tuberculosis (TB) management has failed to control the growing number of drug-
resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate …