In many asthmatics, chronic airway inflammation is driven by IL-4-, IL-5-, and IL-13-
producing Th2 cells or ILC2s. Type 2 cytokines promote hallmark features of the disease …

Eosinophils play a homeostatic role in the body's immune responses. These cells are
involved in combating some parasitic, bacterial, and viral infections and certain cancers and …

Asthma is a chronic disease of the airways, which affects more than 350 million people
worldwide. It is the most common chronic disease in children, affecting at least 30 million …

The intestine harbors a large population of resident eosinophils, yet the function of intestinal
eosinophils has not been explored. Flow cytometry and whole-mount imaging identified …

The enigmatic eosinophil has emerged as an exciting component of the immune system,
involved in a plethora of homeostatic and inflammatory responses. Substantial progress has …

Eosinophilic inflammation is a feature of allergic asthma. Despite mounting evidence
showing that chromatin filaments released from neutrophils mediate various diseases, the …

The neuronal and immune systems exhibit bidirectional interactions that play a critical role in
tissue homeostasis, infection, and inflammation. Neuron-derived neuropeptides and …

Host resistance to Mycobacterium tuberculos is (Mtb) infection requires the activities of
multiple leukocyte subsets, yet the roles of the different innate effector cells during …

Eosinophils are bone marrow-derived granulocytes that, under homeostatic conditions,
account for as much as 1-3% of peripheral blood leukocytes. During inflammation …

In asthma, airway nerve dysfunction leads to excessive bronchoconstriction and cough. It is
well established that eosinophils alter nerve function and that airway eosinophilia is present …