Current clinical landscape and global potential of bacteriophage therapy

NM Hitchcock, D Devequi Gomes Nunes, J Shiach… - Viruses, 2023 - mdpi.com
In response to the global spread of antimicrobial resistance, there is an increased demand
for novel and innovative antimicrobials. Bacteriophages have been known for their potential …

Regulations of phage therapy across the world

Q Yang, S Le, T Zhu, N Wu - Frontiers in Microbiology, 2023 - frontiersin.org
Phage therapy, a century-long treatment targeting bacterial infection, was widely abandoned
after the clinical availability of antibiotics in the mid-20th century. However, the crisis of …

Positive and negative aspects of bacteriophages and their immense role in the food chain

SA Ranveer, V Dasriya, MF Ahmad, HS Dhillon… - npj Science of …, 2024 - nature.com
Bacteriophages infect and replicate inside a bacterial host as well as serve as natural bio-
control agents. Phages were once viewed as nuisances that caused fermentation failures …

The long and sinuous road to phage-based therapy of Clostridioides difficile infections

AA Umansky, LC Fortier - Frontiers in Medicine, 2023 - frontiersin.org
With the antibiotic crisis and the rise in antimicrobial resistance worldwide, new therapeutic
alternatives are urgently needed. Phage therapy represents one of the most promising …

Phage-induced efflux down-regulation boosts antibiotic efficacy

S Kraus, ML Fletcher, U Łapińska, K Chawla… - PLoS …, 2024 - journals.plos.org
The interactions between a virus and its host vary in space and time and are affected by the
presence of molecules that alter the physiology of either the host or the virus. Determining …

Bacteriophage DNA induces an interrupted immune response during phage therapy in a chicken model

M Podlacha, L Gaffke, Ł Grabowski, J Mantej… - Nature …, 2024 - nature.com
One of the hopes for overcoming the antibiotic resistance crisis is the use of bacteriophages
to combat bacterial infections, the so-called phage therapy. This therapeutic approach is …

Automating Predictive Phage Therapy Pharmacology

ST Abedon - Antibiotics, 2023 - mdpi.com
Viruses that infect as well as often kill bacteria are called bacteriophages, or phages.
Because of their ability to act bactericidally, phages increasingly are being employed …

Phage therapy: A renewed approach against oral diseases caused by Enterococcus faecalis infections

Y Xiang, F Song, H Li, X Ji - Microbial Pathogenesis, 2024 - Elsevier
Antibiotics play an important role in the treatment of infectious diseases. Long-term overuse
or misuse of antibiotics, however, has triggered the global crisis of antibiotic resistance …

Bacteriophages for bronchiectasis: treatment of the future?

C Dominic, HV Pye, EK Mishra… - Current Opinion in …, 2024 - journals.lww.com
Bacteriophages for bronchiectasis: treatment of the future? : Current Opinion in Pulmonary
Medicine Bacteriophages for bronchiectasis: treatment of the future? : Current Opinion in …

Combating antimicrobial resistance: a paradigm shift from general to precision medicine

F Ahmed, NJ Shamim, A Das… - Chemical Biology …, 2024 - pubs.thesciencein.org
Antimicrobial resistance (AMR) poses a significant threat to global health. It makes treating
bacterial infections increasingly difficult. AMR arises from various mechanisms of antibiotic …