DNA copy number alterations (CNAs) are genetic changes that can produce adverse effects
in numerous human diseases, including cancer. CNAs are segments of DNA that have been …

We propose a two-step method for the analysis of copy number data. We first define the
partitions of genome aberrations and conditional on the partitions we introduce a …

Tumoral tissues tend to generally exhibit aberrations in DNA copy number that are
associated with the development and progression of cancer. Genotyping methods such as …

Recurrent DNA copy number alterations (CNAs) are key genetic events in the study of
human genetics and disease. Analysis of recurrent DNA CNA data often involves the …

We have developed a statistical method for the analysis of array based CGH data to detect
genomic DNA copy number changes. Our method allows us to answer the biologically …

Karyotyping has been in use in genetics clinics for decades as the standard screening and
diagnostic test for major cytogenetic abnormalities. Many of these abnormalities involve …

In this review article, recent applications of change point methods in genetics will be
discussed. The latest advances in bio‐technology have provided new tools for scientists to …

Array comparative genomic hybridization (aCGH) allows identification of copy number
alterations across genomes. The key computational challenge in analyzing copy number …

Functional data arise frequently in many fields of biomedical research as sequential
observations over time. The observations are generated by an unknown dynamic …

In the past two decades, comparative genomic hybridization (CGH) and array CGH have
become indispensable tools in clinical diagnostics and toxicological risk assessment …