We aim to improve the performance of the previously proposed signal decomposition
matched filtering (SDMF) method [26] for the detection of copy-number variations (CNV) in …

The number of copies of DNA in human cells can be measured using array comparative
genomic hybridization (aCGH), which provides intensity ratios of sample to reference DNA at …

We propose a two-step method for the analysis of copy number data. We first define the
partitions of genome aberrations and conditional on the partitions we introduce a …

Recurrent DNA copy number alterations (CNAs) are key genetic events in the study of
human genetics and disease. Analysis of recurrent DNA CNA data often involves the …

Array comparative genomic hybridization (aCGH) allows identification of copy number
alterations across genomes. The key computational challenge in analyzing copy number …

Functional data arise frequently in many fields of biomedical research as sequential
observations over time. The observations are generated by an unknown dynamic …

In the past two decades, comparative genomic hybridization (CGH) and array CGH have
become indispensable tools in clinical diagnostics and toxicological risk assessment …

In recent years, the rapid development in the field of DNA sequencing techniques has
necessitated the evolution of new computational methods for processing the genomic data …

The overriding goal of this thesis was to further re ne our understanding of the genetic
architecture of cardiomyopathies, Arrhythmogenic Right Ventricular Cardiomyopathy …

MCMC steps. Here we describe our MCMC algorithm in detail. During the update of R (and
of ξ) we first select a list of gene expression, as rows of R (and a list of samples, as elements …