[HTML][HTML] Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for …

PN Pallier, M Ferrara, F Romagnolo, MT Ferretti… - Progress in …, 2022 - Elsevier
Neurological and neuropsychiatric disorders affect men and women differently. Multiple
sclerosis, Alzheimer's disease, anxiety disorders, depression, meningiomas and late-onset …

[HTML][HTML] Extracellular vesicles in mental disorders: a state-of-art review

L Kong, D Zhang, S Huang, J Lai, L Lu… - … journal of biological …, 2023 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) are nanoscale particles with various physiological functions
including mediating cellular communication in the central nervous system (CNS), which …

SARS‐CoV‐2 and mitochondrial proteins in neural‐derived exosomes of COVID‐19

MJ Peluso, SG Deeks, M Mustapic… - Annals of …, 2022 - Wiley Online Library
Objective As SARS‐CoV‐2 is known to invade neural cell mitochondria, a plasma system for
quantifying central nervous system proteins in living humans was used to investigate …

Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder

EJ Goetzl, OM Wolkowitz, VH Srihari, VI Reus… - Molecular …, 2021 - nature.com
To characterize neuronal mitochondrial abnormalities in major depressive disorder (MDD),
functional mitochondrial proteins (MPs) extracted from enriched plasma neuron-derived …

A new diagnostic tool for brain disorders: extracellular vesicles derived from neuron, astrocyte, and oligodendrocyte

X Wang, H Yang, C Liu, K Liu - Frontiers in Molecular Neuroscience, 2023 - frontiersin.org
Brain disorders are the leading cause of disability worldwide, affecting people's quality of life
and causing economic burdens. The current clinical diagnosis of brain disorders relies …

Mitochondrial electron transport chain protein abnormalities detected in plasma extracellular vesicles in Alzheimer's disease

PJ Yao, E Eren, EJ Goetzl, D Kapogiannis - Biomedicines, 2021 - mdpi.com
Mitochondria provide energy to neurons through oxidative phosphorylation and eliminate
Reactive Oxygen Species (ROS) through Superoxide Dismutase 1 (SOD1). Dysfunctional …

[HTML][HTML] Astrocyte-derived extracellular vesicles in stress-associated mood disorders. Does the immune system get astrocytic?

A Luarte, G Nardocci, A Chakraborty, LF Batiz… - Pharmacological …, 2023 - Elsevier
Life stressors can wreak havoc on our health, contributing to mood disorders like major
depressive disorder (MDD), a widespread and debilitating condition. Unfortunately, current …

Neural cell‐derived plasma exosome protein abnormalities implicate mitochondrial impairment in first episodes of psychosis

EJ Goetzl, VH Srihari, S Guloksuz, M Ferrara… - The FASEB …, 2021 - Wiley Online Library
Neuroprotective and other functional proteins of mitochondria were quantified in extracts of
plasma neural‐derived exosomes from ten first‐episode psychosis (FP) patients and ten …

Extracellular vesicle biomarkers for complement dysfunction in schizophrenia

T Xue, W Liu, L Wang, Y Shi, Y Hu, J Yang, G Li… - Brain, 2024 - academic.oup.com
Schizophrenia, a complex neuropsychiatric disorder, frequently experiences a high rate of
misdiagnosis due to subjective symptom assessment. Consequently, there is an urgent …

Machine learning and non-affective psychosis: identification, differential diagnosis, and treatment

M Ferrara, G Franchini, M Funaro, M Cutroni… - Current Psychiatry …, 2022 - Springer
Abstract Purpose of Review This review will cover the most relevant findings on the use of
machine learning (ML) techniques in the field of non-affective psychosis, by summarizing the …