A guide to antigen processing and presentation
Antigen processing and presentation are the cornerstones of adaptive immunity. B cells
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
cannot generate high-affinity antibodies without T cell help. CD4+ T cells, which provide …
[HTML][HTML] Immunogenic cell stress and death
Dying mammalian cells emit numerous signals that interact with the host to dictate the
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
immunological correlates of cellular stress and death. In the absence of reactive antigenic …
Immunotherapies for hepatocellular carcinoma
JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
cause of cancer-related death and its incidence is increasing globally. Around 50% of …
[HTML][HTML] Dendritic cell subsets in cancer immunity and tumor antigen sensing
Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …
Tumour-infiltrating B cells: immunological mechanisms, clinical impact and therapeutic opportunities
CM Laumont, AC Banville, M Gilardi, DP Hollern… - Nature Reviews …, 2022 - nature.com
Although immunotherapy research to date has focused largely on T cells, there is mounting
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …
evidence that tumour-infiltrating B cells and plasma cells (collectively referred to as tumour …
Mechanisms driving the immunoregulatory function of cancer cells
A van Weverwijk, KE de Visser - Nature Reviews Cancer, 2023 - nature.com
Tumours display an astonishing variation in the spatial distribution, composition and
activation state of immune cells, which impacts their progression and response to …
activation state of immune cells, which impacts their progression and response to …
Cellular senescence is immunogenic and promotes antitumor immunity
I Marin, O Boix, A Garcia-Garijo, I Sirois, A Caballe… - Cancer discovery, 2023 - AACR
Cellular senescence is a stress response that activates innate immune cells, but little is
known about its interplay with the adaptive immune system. Here, we show that senescent …
known about its interplay with the adaptive immune system. Here, we show that senescent …
[HTML][HTML] Cancer vaccines: Building a bridge over troubled waters
MLC Sellars, CJ Wu, EF Fritsch - Cell, 2022 - cell.com
Cancer vaccines aim to direct the immune system to eradicate cancer cells. Here we review
the essential immunologic concepts underpinning natural immunity and highlight the …
the essential immunologic concepts underpinning natural immunity and highlight the …
Bioengineered nanogels for cancer immunotherapy
Recent years have witnessed increasingly rapid advances in nanocarrier-based
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …
biomedicine aimed at improving treatment paradigms for cancer. Nanogels serve as …
[HTML][HTML] Hypoxia-inducible factors: master regulators of hypoxic tumor immune escape
Q Wu, L You, E Nepovimova, Z Heger, W Wu… - Journal of hematology & …, 2022 - Springer
Hypoxia, a common feature of the tumor microenvironment in various types of cancers,
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …
weakens cytotoxic T cell function and causes recruitment of regulatory T cells, thereby …