The extracellular matrix (ECM) is essential for cell support during homeostasis and plays a
critical role in cancer. Although research often concentrates on the tumor's cellular aspect …

Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase and an adaptor protein that
primarily regulates adhesion signaling and cell migration. FAK promotes cell survival in …

Breast cancer (BC) involves complex signaling networks characterized by extensive cross-
communication and feedback loops between and within multiple signaling cascades. Many …

The interactions between cells and their surrounding extracellular matrix (ECM) are dynamic
and play critical roles in cell migration during development, health, and diseases. Recent …

Cancer is one of the major causes of mortality and morbidity worldwide. Substantial
research efforts have been made to develop new chemical entities with improved anticancer …

Simple Summary The tumor microenvironment (TME) is composed of various cell types and
extracellular components and plays an important role in cancer development and …

Epigenetic regulation and Focal adhesion kinase (FAK) are considered to be two important
targets for the development of antitumor drugs. Studies have shown that the combination of …

The extracellular matrix (ECM) plays critical roles in cytoskeletal support, biomechanical
transduction and biochemical signal transformation. Tumor-associated macrophage (TAM) …

Focal adhesion kinase (FAK), also known as protein tyrosine kinase 2 (PTK2), is a
ubiquitously expressed non-receptor tyrosine kinase, that plays a pivotal role in integrin …

Pyrimidine has been found in numerous essential components of the organism and plays a
significant role in the human body. Therefore, the derivatives have potent antibacterial and …