Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

The vascular endothelium is vital in maintaining cardiovascular health by regulating
vascular permeability and tone, preventing thrombosis, and controlling vascular …

Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors present a class of antidiabetic
drugs, which inhibit renal glucose reabsorption resulting in the elevation of urinary glucose …

Heart failure is a growing health issue as a negative consequence of improved survival
upon myocardial infarction, unhealthy lifestyle, and the ageing of our population. The large …

Nitric oxide (NO) is a powerful mediator with biological activities such as vasodilation and
prevention of vascular smooth muscle cell proliferation as well as functional regulation of …

Background: Hydrogen sulfide is a critical endogenous signaling molecule that exerts
protective effects in the setting of heart failure. Cystathionine γ-lyase (CSE), 1 of 3 hydrogen …

There is a lack of direct evidence regarding gut microbiota dysbiosis and changes in short-
chain fatty acids (SCFAs) in heart failure (HF) patients. We sought to assess any association …

Heart failure is a complex medical syndrome that is attributed to a number of risk factors;
nevertheless, its clinical presentation is quite similar among the different etiologies. Heart …

Targeted prevention of heart failure (HF) remains a critical need given the high prevalence
of HF morbidity and mortality. Similar to risk-based prevention of atherosclerotic …

The vascular endothelium is localized at the interface between the blood and surrounding
tissues, playing a pivotal role in the maintenance of tissue-fluid homeostasis and in the …