Luteinizing hormone (LH) and follicle-stimulating hormone (FSH) play complementary roles
in follicle development and ovulation via a complex interaction in the hypothalamus, anterior …

Reproduction cannot take place without the proper functioning of the lutropin/
choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does …

Polycystic ovary syndrome (PCOS) is a common metabolic disorder in women. To identify
causative genes, we conducted a genome-wide association study (GWAS) of PCOS in Han …

The recent unraveling of structures of genes for the gonadotropin subunits and gonadotropin
receptors has provided reproductive endocrinologists with new tools to study normal and …

Polycystic ovary syndrome (PCOS) is a common and complex endocrine disorder that
affects 5-20% of reproductive age women. PCOS clinical symptoms include hirsutism …

The ovarian follicle luteinizing hormone (LH) signaling molecules that regulate oocyte
meiotic maturation have recently been identified. The LH signal reduces preovulatory follicle …

▪ Abstract The luteinizing hormone receptor (LHR) is a member of the subfamily of
glycoprotein hormone receptors within the superfamily of G protein–coupled receptor …

Premature ovarian failure (POF) is a common cause of infertility in women, characterized by
amenorrhea, hypoestrogenism, and elevated gonadotropin levels in women under the age …

Synthesis and maturation of G protein-coupled receptors are complex events that require an
intricate combination of processes that include protein folding, post-translational …

The melanocortin-4 receptor (MC4R) is a member of the rhodopsin-like G protein-coupled
receptor family. The binding of α-MSH to the MC4R leads to increased cAMP production …