Aortic aneurysm, including both abdominal aortic aneurysm and thoracic aortic aneurysm, is
the cause of death of 1% to 2% of the Western population. This review focuses only on …

Marfan syndrome (MFS) is a pleiotropic connective tissue disease inherited as an autosomal
dominant trait, due to mutations in the FBN1 gene encoding fibrillin 1. It is an important …

Importance The prevalence and characteristics of bicuspid aortic valve (BAV) are mainly
reported from selected cohorts. BAV is associated with aortopathy, but it is unclear if it …

Bicuspid aortic valve (BAV) is a heritable congenital heart defect and an important risk factor
for valvulopathy and aortopathy. Here we report a genome-wide association scan of 466 …

Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal-dominant connective tissue
disorder caused by heterozygous mutations in the COL3A1 gene, which encodes the pro-α …

Zinc is structurally and functionally essential for more than 300 enzymes and 2000
transcription factors in human body. Intracellular labile zinc is the metabolically effective zinc …

Research on bicuspid aortic valves (BAV) and associated conditions is increasing
exponentially. A major part of the current knowledge on BAV is derived from investigations …

OBJECTIVES Different methods to classify the anatomical configurations of the aorta with
bicuspid aortic valve (BAV) have been proposed. We aimed to test them in terms of …

Calcific aortic valve stenosis (CAVS) is among the most common causes of cardiovascular
mortality in an aging population worldwide. The pathomechanisms of CAVS are such a …

Bicuspid aortic valve (BAV), the most common congenital valvular abnormality, generates
asymmetric flow patterns and increased stresses on the leaflets that expedite valvular …