Microbial dysbiosis and polyamine metabolism as predictive markers for early detection of pancreatic cancer

R Mendez, K Kesh, N Arora, L Di Martino… - …, 2020 - academic.oup.com
The lack of tools for early detection of pancreatic ductal adenocarcinoma (PDAC) is directly
correlated with the abysmal survival rates in patients. In addition to several potential …

The varied role of efflux pumps of the MFS family in the interplay of bacteria with animal and plant cells

M Pasqua, M Grossi, A Zennaro, G Fanelli, G Micheli… - Microorganisms, 2019 - mdpi.com
Efflux pumps represent an important and large group of transporter proteins found in all
organisms. The importance of efflux pumps resides in their ability to extrude a wide range of …

Gut dysbacteriosis and intestinal disease: mechanism and treatment

X Meng, G Zhang, H Cao, D Yu, X Fang… - Journal of applied …, 2020 - academic.oup.com
The gut microbiome functions like an endocrine organ, generating bioactive metabolites,
enzymes or small molecules that can impact host physiology. Gut dysbacteriosis is …

Sporadic colorectal cancer: microbial contributors to disease prevention, development and therapy

JL Drewes, F Housseau, CL Sears - British journal of cancer, 2016 - nature.com
The gut microbiota has been hailed as an accessory organ, with functions critical to the host
including dietary metabolic activities and assistance in the development of a proper …

Metabolomics of tomato xylem sap during bacterial wilt reveals Ralstonia solanacearum produces abundant putrescine, a metabolite that accelerates wilt disease

TM Lowe‐Power, CG Hendrich… - Environmental …, 2018 - Wiley Online Library
Ralstonia solanacearum thrives in plant xylem vessels and causes bacterial wilt disease
despite the low nutrient content of xylem sap. We found that R. solanacearum manipulates …

[HTML][HTML] The colonic microbiome and epithelial transcriptome are altered in rats fed a high-protein diet compared with a normal-protein diet

C Mu, Y Yang, Z Luo, L Guan, W Zhu - The Journal of nutrition, 2016 - Elsevier
Background: A high-protein diet (HPD) can produce hazardous compounds and reduce
butyrate-producing bacteria in feces, which may be detrimental to gut health. However …

The Intriguing Evolutionary Journey of Enteroinvasive E. coli (EIEC) toward Pathogenicity

M Pasqua, V Michelacci, ML Di Martino… - Frontiers in …, 2017 - frontiersin.org
Among the intestinal pathogenic Escherichia coli, enteroinvasive E. coli (EIEC) are a group
of intracellular pathogens able to enter epithelial cells of colon, multiplicate within them, and …

Endogenous polyamine function—the RNA perspective

HL Lightfoot, J Hall - Nucleic acids research, 2014 - academic.oup.com
Recent progress with techniques for monitoring RNA structure in cells such as 'DMS-
Seq'and 'Structure-Seq'suggests that a new era of RNA structure-function exploration is on …

The molecular and physiological effects of protein-derived polyamines in the intestine

AF Bekebrede, J Keijer, WJJ Gerrits, VCJ Boer - Nutrients, 2020 - mdpi.com
Consumption of a high-protein diet increases protein entry into the colon. Colonic microbiota
can ferment proteins, which results in the production of protein fermentation end-products …

Microbiota–host transgenomic metabolism, bioactive molecules from the inside: Miniperspective

S Turroni, P Brigidi, A Cavalli… - Journal of medicinal …, 2018 - ACS Publications
Molecular factors from the gut microbiota provide the host with the right metabolic,
immunological, and neurological components to support health and well-being. However …