Accumulating lines of experimental evidence have revealed that hypoxia‐inducible factors,
HIF‐1α and HIF‐2α, are key regulators of the adaptation of cancer‐and metastasis‐initiating …

The mitogen-activated extracellular signal-regulated kinase (MEK) pathway is one of the
best-characterized kinase cascades in cancer cell biology. It is triggered by either growth …

There is growing evidence that metabolic alterations play an important role in cancer
development and progression. The metabolism of cancer cells is reprogrammed in order to …

Background Recently, progress has been made in the development of targeted therapies for
human epidermal growth factor receptor 2 (HER2)-positive gastric cancer (GC). However …

Transcription factor Krüppel-like factors 5 (KLF5) is overexpressed in a wide range of tumor
tissues and acts as a prognostic factor in cancer. However, the role of KLF5 in non-small cell …

Epithelial to mesenchymal transition (EMT) is a well-defined cellular process that was
discovered in chicken embryos and described as “epithelial to mesenchymal …

Primary sclerosing cholangitis (PSC) is characterized by increased mast cell (MC)
infiltration, biliary damage and hepatic fibrosis. Cholangiocytes secrete stem cell factor …

Pancreatic cancer is one of the most fatal human malignancies. Though a relatively rare
malignancy, it remains one of the deadliest tumors, with an extremely high mortality rate. The …

Background Therapy resistance remains one of the major challenges to improve the
prognosis of patients with pancreatic cancer. Chemoresistant cells, which potentially also …

Abstract Study Objective: The presence of obstructive sleep apnea (OSA) in patients with
cancer appears to be accompanied by poorer outcomes. However, the mechanisms …