The advent of iPSCs has brought about a significant transformation in stem cell research,
opening up promising avenues for advancing cancer treatment. The formation of cancer is a …

Our understanding of the molecular mechanisms underlying cancer development and
evolution have evolved rapidly over recent years, and the variation from one patient to …

Identifying synergistic drug combinations (SDCs) is a great challenge due to the
combinatorial complexity and the fact that SDC is cell line specific. The existing …

Clear cell renal cell carcinoma (ccRCC) is one of the tumor types with sensitivity to
ferroptosis, and immunotherapy has emerged as a standard pillar for metastatic ccRCC …

Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …

Tumors exhibit a variety of strategies to dampen antitumor immune responses. With an aim
to identify factors that are secreted from tumor cells, we performed an unbiased mass …

Bladder cancer (BCa) is a life-threaten disease with an increasing incidence with age, and
immunotherapy has become an important treatment for BCa, while the efficiency of the …

The druggable genome is limited by structural features that can be targeted by small
molecules in disease-relevant proteins. While orthosteric and allosteric protein modulators …

Simple Summary Omics technologies and targeted drugs are revolutionizing the clinical
oncology landscape, portending the promise of precision oncology. However, our abilities to …

Background Precision medicine (PM) is a form of personalized medicine that recognizes that
individuals with the same condition may have different underlying factors and uses …