Objective To evaluate the impact of early treatment and IL1RN genetic variants on the
response to anakinra in systemic juvenile idiopathic arthritis (JIA). Methods Response to …

Background Carcinogenesis is a multi-step process indicated by several genes up-or down-
regulated during tumor progression. This study examined and identified differentially …

Background Obesity has been recognized as a worldwide growing problem, producing
many pathologies including the promotion of “proinflammatory state.” The etiology of human …

OBJECTIVE: The purpose of this study was to evaluate the use of local capsaicin cream as
an effective treatment for patients with documented vulvar vestibulitis syndrome. STUDY …

Recent gene-expression data have suggested that host immune genetic signatures may
predict outcomes in patients with follicular lymphoma. We evaluated the hypothesis that …

近年来对白介素(interleukin, IL) 和溃疡性结肠炎(ulcerative colitis, UC) 的研究取得了很大进展,
我们通过总结整理以前有关IL 和UC 的文献, 概括出IL 的产生和在UC 发病及病理变化中的作用 …

Many factors may influence the risk of being infected by SARS-CoV-2, the coronavirus
responsible for coronavirus disease 2019 (COVID-19). Exposure to the virus cannot explain …

Objective To study the role of the interleukin‐1β gene (IL1B) and the IL‐1 receptor
antagonist gene (IL1RN) in relation to the occurrence of radiographic osteoarthritis (ROA) in …

Inflammation is crucial to tumorigenesis and progression of many cancers. Inflammatory
molecules in tumor microenvironment exert pro-or anti-tumor effects. Among them …

Objective: Certain forms of primary osteoarthritis (OA), particularly those affecting hand
joints, have a genetic component. Recent studies have shown suggestive evidence that …