Sex steroid hormones, hormonal contraception, and the immunobiology of human immunodeficiency virus-1 infection

Z Hel, E Stringer, J Mestecky - Endocrine reviews, 2010 - academic.oup.com
Worldwide, an increasing number of women use oral or injectable hormonal contraceptives.
However, inadequate information is available to aid women and health care professionals in …

Clinical development of microbicides for the prevention of HIV infection

OJ D'Cruz, FM Uckun - Current pharmaceutical design, 2004 - ingentaconnect.com
The HIV/AIDS pandemic continues its spread at a rate of over 15,000 new infections every
day. Sexual transmission of HIV-1 is the dominant mode of this pandemic spread. For the …

The anti-inflammatory activity of curcumin protects the genital mucosal epithelial barrier from disruption and blocks replication of HIV-1 and HSV-2

VH Ferreira, A Nazli, SE Dizzell, K Mueller, C Kaushic - PloS one, 2015 - journals.plos.org
Inflammation is a known mechanism that facilitates HIV acquisition and the spread of
infection. In this study, we evaluated whether curcumin, a potent and safe anti-inflammatory …

PPARγ and LXR Signaling Inhibit Dendritic Cell-Mediated HIV-1 Capture and trans-Infection

TM Hanley, W Blay Puryear, S Gummuluru… - PLoS …, 2010 - journals.plos.org
Dendritic cells (DCs) contribute to human immunodeficiency virus type 1 (HIV-1)
transmission and dissemination by capturing and transporting infectious virus from the …

Chlamydia trachomatis Infection of Endocervical Epithelial Cells Enhances Early HIV Transmission Events

LR Buckner, AM Amedee, HL Albritton, PA Kozlowski… - PloS one, 2016 - journals.plos.org
Chlamydia trachomatis causes a predominantly asymptomatic, but generally inflammatory,
genital infection that is associated with an increased risk for HIV acquisition. Endocervical …

Live imaging of HIV-1 transfer across T cell virological synapse to epithelial cells that promotes stromal macrophage infection

F Real, A Sennepin, Y Ganor, A Schmitt, M Bomsel - Cell reports, 2018 - cell.com
During sexual intercourse, HIV-1 crosses epithelial barriers composing the genital mucosa,
a poorly understood feature that requires an HIV-1-infected cell vectoring efficient mucosal …

[HTML][HTML] HIV is inactivated after transepithelial migration via adult oral epithelial cells but not fetal epithelial cells

SM Tugizov, R Herrera, P Veluppillai, D Greenspan… - Virology, 2011 - Elsevier
Oral transmission of human immunodeficiency virus (HIV) in adult populations is rare.
However, HIV spread across fetal/neonatal oropharyngeal epithelia could be important in …

Medroxyprogesterone acetate regulates HIV-1 uptake and transcytosis but not replication in primary genital epithelial cells, resulting in enhanced T-cell infection

VH Ferreira, S Dizzell, A Nazli, JK Kafka… - The Journal of …, 2015 - academic.oup.com
Although clinical and experimental evidence indicates that female sex hormones and
hormonal contraceptives regulate susceptibility to human immunodeficiency virus type 1 …

HIV-1 virological synapse is not simply a copycat of the immunological synapse

G Vasiliver-Shamis, ML Dustin, CE Hioe - Viruses, 2010 - mdpi.com
The virological synapse (VS) is a tight adhesive junction between an HIV-infected cell and
an uninfected target cell, across which virus can be efficiently transferred from cell to cell in …

[HTML][HTML] R5-and X4-HIV-1 use differentially the endometrial epithelial cells HEC-1A to ensure their own spread: implication for mechanisms of sexual transmission

H Saïdi, G Magri, N Nasreddine, M Réquena, L Bélec - Virology, 2007 - Elsevier
The mechanism of viral transmission across the mucosal barrier is poorly understood. Using
the endometrial epithelium-derived cell line HEC-1A, we found that the cells are capable of …