Sex, glia, and development: interactions in health and disease

JM Schwarz, SD Bilbo - Hormones and behavior, 2012 - Elsevier
This article is part of a Special Issue “Neuroendocrine-Immune Axis in Health and Disease.”
Microglia and astrocytes are the primary immune cells within the central nervous system …

New approaches in the management of multiple sclerosis

LJ Barten, DR Allington, KA Procacci… - Drug design …, 2010 - Taylor & Francis
Multiple sclerosis (MS) is a central nervous system chronic inflammatory disease that is
characterized by an extensive and complex immune response. Scientific advances have …

Sex differences in microglial colonization of the developing rat brain

JM Schwarz, PW Sholar, SD Bilbo - Journal of neurochemistry, 2012 - Wiley Online Library
J. Neurochem.(2012) 120, 948–963. Abstract Microglia are the resident immune cells within
the brain and their production of immune molecules such as cytokines and chemokines is …

Anti-inflammatory effects of β-lapachone in lipopolysaccharide-stimulated BV2 microglia

DO Moon, YH Choi, ND Kim, YM Park… - International …, 2007 - Elsevier
β-Lapachone (LAPA) is a chemotherapeutic agent that can inhibit the expression of nitric
oxide (NO) and inducible NO synthase (iNOS) in alveolar macrophages. No other …

Estriol generates tolerogenic dendritic cells in vivo that protect against autoimmunity

TL Papenfuss, ND Powell, MA McClain… - The Journal of …, 2011 - journals.aai.org
Chronic inflammation contributes to numerous diseases, and regulation of inflammation is
crucial for disease control and resolution. Sex hormones have potent immunoregulatory …

Recent use of oral contraceptives and the risk of multiple sclerosis

Á Alonso, SS Jick, MJ Olek, A Ascherio… - Archives of …, 2005 - jamanetwork.com
Background Exogenous estrogens affect the onset and clinical course of experimental
allergic encephalomyelitis. Oral contraceptives, a frequent source of exogenous estrogens …

The role of sex hormones in multiple sclerosis

M Avila, A Bansal, J Culberson, AN Peiris - European neurology, 2018 - karger.com
Multiple sclerosis (MS) is a chronic inflammatory demyelination disorder with an immune-
mediated pathophysiology that affects the central nervous system (CNS). Like other …

Estrogen protection against EAE modulates the microbiota and mucosal-associated regulatory cells

G Benedek, J Zhang, H Nguyen, G Kent… - Journal of …, 2017 - Elsevier
Sex hormones promote immunoregulatory effects on multiple sclerosis. In the current study
we evaluated the composition of the gut microbiota and the mucosal-associated regulatory …

SJL mice exposed to cuprizone intoxication reveal strain and gender pattern differences in demyelination

LC Taylor, W Gilmore, GK Matsushima - Brain Pathology, 2009 - Wiley Online Library
The role of mouse strain and the influence of gender on demyelination were explored for the
first time in SJL mice using the cuprizone intoxication model. We document here that SJL …

Estrogen induces multiple regulatory B cell subtypes and promotes M2 microglia and neuroprotection during experimental autoimmune encephalomyelitis

G Benedek, J Zhang, S Bodhankar, H Nguyen… - Journal of …, 2016 - Elsevier
Sex hormones promote immunoregulatory effects on multiple sclerosis. The current study
evaluated estrogen effects on regulatory B cells and resident CNS microglia during …