Abstract The PI3K/AKT/mTOR (PAM) signaling pathway is a highly conserved signal
transduction network in eukaryotic cells that promotes cell survival, cell growth, and cell …

Breast cancer (BC) is the most frequent cancer diagnosed in women worldwide. This
heterogeneous disease can be classified into four molecular subtypes (luminal A, luminal B …

Breast cancer is the second leading cause of cancer deaths among women. The
development of breast cancer is a multi-step process involving multiple cell types, and its …

Protein tyrosine kinase (PTK) is one of the major signaling enzymes in the process of cell
signal transduction, which catalyzes the transfer of ATP-γ-phosphate to the tyrosine residues …

Glycogen synthase kinase 3 (GSK-3) is a serine/threonine (S/T) protein kinase. Although
GSK-3 originally was identified to have functions in regulation of glycogen synthase, it was …

Breast cancer is the cancer with the highest prevalence in women and is the number‐one
cause of cancer mortality worldwide. Cell transduction is a fundamental process in the …

The mechanisms behind cancer initiation and progression are not clear. Therefore,
development of clinically relevant models to study cancer biology and drug response in …

Plant-derived compounds have recently attracted greater interest in the field of new
therapeutic agent development. These compounds have been widely screened for their …

Nowadays, diet and specific dietary supplements are seen as potential adjuvants to prevent
different chronic diseases, including cancer, or to ameliorate pharmacological therapies …

Abstract Glycogen synthase kinase-3 (GSK-3) is a serine/threonine kinase that participates
in an array of critical cellular processes. GSK-3 was first characterized as an enzyme that …