Abstract Type 2 diabetes (T2D) is a widely prevalent disease with substantial economic and
social impact for which multiple conventional and novel pharmacotherapies are currently …

Metformin is a well-known anti-diabetic drug that has been repurposed for several emerging
applications, including as an anti-cancer agent. It boasts the distinct advantages of an …

The main challenges for programmed cell death 1 (PD-1)/PD-1 ligand (PD-L1) checkpoint
blockade lie in a lack of sufficient T cell infiltration, tumor immunosuppressive …

Metformin is a lipophilic biguanide which inhibits hepatic gluconeogenesis and improves
peripheral utilization of glucose. It is the first line pharmacotherapy for glucose control in …

Metformin is a broadly prescribed drug for type 2 diabetes that exerts antitumor activity, yet
the mechanisms underlying this activity remain unclear. We show here that metformin …

Metformin is everywhere. Originally introduced in clinical practice as an antidiabetic agent,
its role as a therapeutic agent is expanding to include treatment of prediabetes mellitus …

The quest to repurpose metformin, an antidiabetes drug, as an agent for cancer prevention
and treatment, which began in 2005 with an observational study that reported a reduction in …

Increasing evidence shows that Traditional Chinese Medicine (TCM) has an obvious appeal
for cancer treatment, but there is still a lack of scientific investigation of its underlying …

Mangroves are ecologically important plants in marine habitats that occupy the coastlines of
many countries. In addition to their key ecological importance, various parts of mangroves …

Metformin, a US Food and Drug Administration-approved “star” drug used for diabetes
mellitus type 2, has become a topic of increasing interest to researchers due to its anti …