Mechanisms of microtubule organization in differentiated animal cells

A Akhmanova, LC Kapitein - Nature Reviews Molecular Cell Biology, 2022 - nature.com
Microtubules are polarized cytoskeletal filaments that serve as tracks for intracellular
transport and form a scaffold that positions organelles and other cellular components and …

Conservation of oocyte development in germline cysts from Drosophila to mouse

AC Spradling, W Niu, Q Yin, M Pathak, B Maurya - Elife, 2022 - elifesciences.org
Recent studies show that pre-follicular mouse oogenesis takes place in germline cysts,
highly conserved groups of oogonial cells connected by intercellular bridges that develop as …

Polarized microtubule remodeling transforms the morphology of reactive microglia and drives cytokine release

M Adrian, M Weber, MC Tsai, C Glock, OI Kahn… - Nature …, 2023 - nature.com
Microglial reactivity is a pathological hallmark in many neurodegenerative diseases. During
stimulation, microglia undergo complex morphological changes, including loss of their …

O‐GlcNAcylation Regulates Centrosome Behavior and Cell Polarity to Reduce Pulmonary Fibrosis and Maintain the Epithelial Phenotype

F Yu, S Yang, H Ni, D Heng, X Wu, M Yang… - Advanced …, 2023 - Wiley Online Library
O‐GlcNAcylation functions as a cellular nutrient and stress sensor and participates in almost
all cellular processes. However, it remains unclear whether O‐GlcNAcylation plays a role in …

Principles of organelle positioning in motile and non-motile cells

J Kroll, J Renkawitz - EMBO reports, 2024 - embopress.org
Cells are equipped with asymmetrically localised and functionally specialised components,
including cytoskeletal structures and organelles. Positioning these components to specific …

Microtubule organization is essential for maintaining cellular morphology and function

L Huang, Y Peng, X Tao, X Ding, R Li… - Oxidative medicine …, 2022 - Wiley Online Library
Microtubules (MTs) are highly dynamic polymers essential for a wide range of cellular
physiologies, such as acting as directional railways for intracellular transport and position …

Self-organization of cellular units

TJ Mitchison, CM Field - Annual review of cell and …, 2021 - annualreviews.org
The purpose of this review is to explore self-organizing mechanisms that pattern
microtubules (MTs) and spatially organize animal cell cytoplasm, inspired by recent …

[HTML][HTML] Microglia reactivity entails microtubule remodeling from acentrosomal to centrosomal arrays

M Rosito, C Sanchini, G Gosti, M Moreno, S De Panfilis… - Cell reports, 2023 - cell.com
Microglia reactivity entails a large-scale remodeling of cellular geometry, but the behavior of
the microtubule cytoskeleton during these changes remains unexplored. Here we show that …

[HTML][HTML] ER and Golgi trafficking in axons, dendrites, and glial processes

S Kemal, HS Richardson, ED Dyne, M Fu - Current opinion in cell biology, 2022 - Elsevier
Both neurons and glia in mammalian brains are highly ramified. Neurons form complex
neural networks using axons and dendrites. Axons are long with few branches and form pre …

Microtubule anchoring: attaching dynamic polymers to cellular structures

C Vineethakumari, J Lüders - Frontiers in Cell and Developmental …, 2022 - frontiersin.org
Microtubules are dynamic, filamentous polymers composed of α-and β-tubulin. Arrays of
microtubules that have a specific polarity and distribution mediate essential processes such …