Background The development of drug-resistant (DR) tuberculosis (TB) has become an
increasing concern over the past few decades as the result of numerous factors, including …

Ventriculitis or post-neurosurgical meningitis or healthcare-associated ventriculitis and
meningitis (VM) is a severe infection that complicates central nervous system operations or …

What is known and objective Meropenem, a carbapenem antibiotic, is widely prescribed for
the treatment of life‐threatening infections. The main parameter associated with its …

Infections of the central nervous system (CNS) are complex to treat and associated with
significant morbidity and mortality. Historically, antistaphylococcal penicillins such as …

The challenging severity of some infections, especially in critically ill patients, makes the
diffusion of antimicrobial drugs within tissues one of the cornerstones of chemotherapy. The …

The current antimicrobial therapy of bacterial infections of the central nervous system (CNS)
in adults and pediatric patients is faced with many pitfalls as the drugs have to reach …

Critically ill patients admitted to intensive care unit (ICU) with severe infections, or those who
develop nosocomial infections, have poor outcomes with substantial morbidity and mortality …

ABSTRACT Introduction 9–20% of the patients with an external ventricular drain develop a
catheter-associated infection. Areas covered This review summarizes the diagnostic process …

Drain-associated intracerebral infections are life-threatening emergencies. Their treatment is
challenging due to the limited penetration of antibiotics to the site of infection, resulting in …

Clinicians should maintain a high index of suspicion for healthcare-associated central
nervous system infections in patients with specific risk factors (ie recent neurosurgery …