[HTML][HTML] Exosomes: key players in cancer and potential therapeutic strategy

J Dai, Y Su, S Zhong, L Cong, B Liu, J Yang… - Signal transduction and …, 2020 - nature.com
Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in
intercellular communication. The components of exosomes, including proteins, DNA, mRNA …

[HTML][HTML] Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology

A Yokoi, T Ochiya - Seminars in cancer biology, 2021 - Elsevier
Extracellular vesicles (EVs) such as exosomes are released by all living cells and contain
diverse bioactive molecules, including nucleic acids, proteins, lipids, and metabolites …

[HTML][HTML] Exosomes and their role in cancer progression

Y Liu, K Shi, Y Chen, X Wu, Z Chen, K Cao… - Frontiers in …, 2021 - frontiersin.org
Exosomes from extracellular vesicles can activate or inhibit various signaling pathways by
transporting proteins, lipids, nucleic acids and other substances to recipient cells. In …

Effect of platelet exosomes loaded with doxorubicin as a targeted therapy on triple-negative breast cancer cells

D Uslu, BI Abas, GM Demirbolat, O Cevik - Molecular Diversity, 2024 - Springer
Exosomes have come to the fore in drug delivery systems due to their biological-based and
immune-suppressing properties. In this study, we investigated the effect of doxorubicin …

Exosomes derived from human bone marrow mesenchymal stem cells transfer miR-222-3p to suppress acute myeloid leukemia cell proliferation by targeting IRF2 …

F Zhang, Y Lu, M Wang, J Zhu, J Li, P Zhang… - Molecular and cellular …, 2020 - Elsevier
Aim This study aims to explore the role and mechanism of exosomes derived from human
bone marrow mesenchymal stem cells (hBM-MSCs-Exo) in regulating proliferation and …

[HTML][HTML] Overcoming the immunosuppressive tumor microenvironment in multiple myeloma

FM Uckun - Cancers, 2021 - mdpi.com
Simple Summary This article provides a comprehensive review of new and emerging
treatment strategies against multiple myeloma that employ precision medicines and/or drugs …

[HTML][HTML] Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related myocardial damage

R Sun, W Liu, Y Zhao, H Chen, Z Wang, Y Zhang… - Cancer Cell …, 2021 - Springer
Introduction Myocardial damage is a mostly incurable complication of multiple myeloma
(MM) that seriously affects the treatment outcome and quality of life of patients. Exosomal …

[HTML][HTML] Roles of the exosomes derived from myeloid-derived suppressor cells in tumor immunity and cancer progression

Z Chen, R Yuan, S Hu, W Yuan, Z Sun - Frontiers in immunology, 2022 - frontiersin.org
Tumor immunity is involved in malignant tumor progression. Myeloid-derived suppressor
cells (MDSCs) play an irreplaceable role in tumor immunity. MDSCs are composed of …

[HTML][HTML] Exosomes in the pathogenesis and treatment of multiple myeloma in the context of the bone marrow microenvironment

T Chen, M Moscvin, G Bianchi - Frontiers in Oncology, 2020 - frontiersin.org
Multiple myeloma (MM), the second most common hematological malignancy, is an
incurable cancer of plasma cells. MM cells diffusely involves the bone marrow (BM) and …

Pathogenesis and treatment of multiple myeloma

P Yang, Y Qu, M Wang, B Chu, W Chen, Y Zheng… - MedComm, 2022 - Wiley Online Library
Multiple myeloma (MM) is the second‐ranking malignancy in hematological tumors. The
pathogenesis of MM is complex with high heterogeneity, and the development of the …