Abstract The three-dimensional (3D) multicellular tumor spheroids (MCTs) model is
becoming an essential tool in cancer research as it expresses an intermediate complexity …

Simple Summary Three-dimensional (3D) cell culture models have been proposed as
alternatives for initial drug screening to increase drug development efficiency. In addition to …

Synthetic gene circuits that precisely control human cell function could expand the
capabilities of gene-and cell-based therapies. However, platforms for developing circuits in …

Three-dimensional (3D) culture systems have fueled hopes to bring about the next
generation of more physiologically relevant high-throughput screens (HTS). However …

Drug development is a time-consuming and expensive process, given the low success rate
of clinical trials. Now, anticancer drug developments have shifted to three-dimensional (3D) …

Abstract Three-dimensional (3D) cell culture has tremendous advantages to closely mimic
the in vivo architecture and microenvironment of healthy tissue and organs, as well as of …

Cancer immunotherapy is the great breakthrough in cancer treatment as it displayed
prolonged progression-free survival over conventional therapies, yet, to date, in only a …

Immunotherapy as a rapidly developing therapeutic approach has revolutionized cancer
treatment and revitalized the field of tumor immunology research. 3D in vitro models are …

Currently, the demand for more reliable drug screening devices has made scientists and
researchers develop novel potential approaches to offer an alternative to animal studies …

Background Triple negative breast cancer (TNBC) is an aggressive disease characterized
by high risk of relapse and development of resistance to different chemotherapy agents …