[HTML][HTML] Cytokines in atherosclerosis: Key players in all stages of disease and promising therapeutic targets
Atherosclerosis, a chronic inflammatory disorder of the arteries, is responsible for most
deaths in westernized societies with numbers increasing at a marked rate in developing …
deaths in westernized societies with numbers increasing at a marked rate in developing …
Liver X receptors: regulators of cholesterol metabolism, inflammation, autoimmunity, and cancer
MT Bilotta, S Petillo, A Santoni, M Cippitelli - Frontiers in immunology, 2020 - frontiersin.org
The interplay between cellular stress and immune response can be variable and sometimes
contradictory. The mechanisms by which stress-activated pathways regulate the …
contradictory. The mechanisms by which stress-activated pathways regulate the …
Amelioration of Tau and ApoE4-linked glial lipid accumulation and neurodegeneration with an LXR agonist
Apolipoprotein E (APOE) is a strong genetic risk factor for late-onset Alzheimer's disease
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …
(LOAD). APOE4 increases and APOE2 decreases risk relative to APOE3. In the P301S …
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis
Cholesterol biosynthetic intermediates, such as lanosterol and desmosterol, are emergent
immune regulators of macrophages in response to inflammatory stimuli or lipid overloading …
immune regulators of macrophages in response to inflammatory stimuli or lipid overloading …
Endosomal cholesterol in viral infections–a common denominator?
M Glitscher, E Hildt - Frontiers in Physiology, 2021 - frontiersin.org
Cholesterol has gained tremendous attention as an essential lipid in the life cycle of virtually
all viruses. These seem to have developed manifold strategies to modulate the cholesterol …
all viruses. These seem to have developed manifold strategies to modulate the cholesterol …
The nuclear receptor LXR limits bacterial infection of host macrophages through a mechanism that impacts cellular NAD metabolism
Macrophages exert potent effector functions against invading microorganisms but constitute,
paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of …
paradoxically, a preferential niche for many bacterial strains to replicate. Using a model of …
The role of interferon-γ in cardiovascular disease: an update
A Elyasi, I Voloshyna, S Ahmed, LJ Kasselman… - Inflammation …, 2020 - Springer
Purpose Cardiovascular disease (CVD) is the leading cause of death, globally, and its
prevalence is only expected to rise due to the increasing incidence of co-morbidities such as …
prevalence is only expected to rise due to the increasing incidence of co-morbidities such as …
The role of macrophage TAM receptor family in the acute‐to‐chronic progression of liver disease: From friend to foe?
H Huang, J Jiang, R Chen, Y Lin, H Chen… - Liver …, 2022 - Wiley Online Library
Hepatic macrophages, the key cellular components of the liver, emerge as essential players
in liver inflammation, tissue repair and subsequent fibrosis, as well as tumorigenesis …
in liver inflammation, tissue repair and subsequent fibrosis, as well as tumorigenesis …
Anti-diabetic rosiglitazone remodels the adipocyte transcriptome by redistributing transcription to PPARγ-driven enhancers
SE Step, HW Lim, JM Marinis, A Prokesch… - Genes & …, 2014 - genesdev.cshlp.org
Rosiglitazone (rosi) is a powerful insulin sensitizer, but serious toxicities have curtailed its
widespread clinical use. Rosi functions as a high-affinity ligand for peroxisome proliferator …
widespread clinical use. Rosi functions as a high-affinity ligand for peroxisome proliferator …
Microglia and cholesterol handling: Implications for Alzheimer's disease
OM Muñoz Herrera, AM Zivkovic - Biomedicines, 2022 - mdpi.com
Cholesterol is essential for brain function and structure, however altered cholesterol
metabolism and transport are hallmarks of multiple neurodegenerative conditions, including …
metabolism and transport are hallmarks of multiple neurodegenerative conditions, including …