The precise mechanisms by which oxidative stress (OS) causes atrial fibrillation (AF) are not
known. Since AF frequently originates in the posterior left atrium (PLA), we hypothesized that …

Computational models in physiology often integrate functional and structural information
from a large range of spatiotemporal scales from the ionic to the whole organ level. Their …

Human pluripotent stem cell-derived cardiomyocytes (PSC-CMs) have great potential
application in almost all areas of cardiovascular research. A current major goal of the field is …

Abstract Intracellular calcium (Ca2+) cycling is tightly regulated in the healthy heart ensuring
effective contraction. This is achieved by transverse (t)‐tubule membrane invaginations that …

The most common sustained cardiac arrhythmias in humans are atrial tachyarrhythmias,
mainly atrial fibrillation. Areas of complex fractionated atrial electrograms and high dominant …

Advanced computational techniques and mathematical modeling have become more and
more important to the study of cardiac electrophysiology. In this review, we provide a brief …

Aims Despite numerous reports documenting an important role of hypertension in the
development of atrial fibrillation (AF), the detailed mechanism underlying the pathological …

Abstract Background and Objective Computer-aided diagnosis (CAD) of Myocardial
Infarction (MI) using machine learning depends on a large amount of clinical …

Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid
arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can …

Calcium plays a crucial role in excitation-contraction coupling (ECC), but it is also a pivotal
second messenger activating Ca 2+-dependent transcription factors in a process termed …