Aims Despite numerous reports documenting an important role of hypertension in the
development of atrial fibrillation (AF), the detailed mechanism underlying the pathological …

Calcium plays a crucial role in excitation-contraction coupling (ECC), but it is also a pivotal
second messenger activating Ca2+-dependent transcription factors in a process termed …

Spontaneous sub-cellular calcium release events (SCRE) are conjectured to promote rapid
arrhythmias associated with conditions such as heart failure and atrial fibrillation: they can …

The complexity of the heart makes an intuitive understanding of the relative contribution of
ion channels, transporters and signalling pathways to cardiac electrophysiology …

Chronic atrial fibrillation (AF) is a complex disease with underlying changes in
electrophysiology, calcium signaling and the structure of atrial myocytes. How these …

Highlights•Modelling and simulation can streamline decision making in drug safety
testing.•Computational cardiac electrophysiology is a mature technology with a long …

Anatomically based procedures to ablate atrial fibrillation (AF) are often successful in
terminating paroxysmal AF. However, the ability to terminate persistent AF remains …

Abstract Background and Objective Computer-aided diagnosis (CAD) of Myocardial
Infarction (MI) using machine learning depends on a large amount of clinical …

Mitochondrial Ca2+ is known to change dynamically, regulating mitochondrial as well as
cellular functions such as energy metabolism and apoptosis. The NCLX gene encodes the …

Over the last decade, the state‐of‐the‐art in cardiac computational modelling has
progressed rapidly. The electrophysiological function of the heart can now be simulated with …