The extracellular matrix (ECM) surrounds cells in the brain, providing structural and
functional support. Emerging studies demonstrate that the ECM plays important roles during …

ABSTRACT Introduction Cerebellar ataxias (CAs) represent neurological disorders with
multiple etiologies and a high phenotypic variability. Despite progress in the understanding …

Gait ataxia is one of the most common and impactful consequences of cerebellar
dysfunction. Purkinje cells, the sole output neurons of the cerebellar cortex, are often …

Spinocerebellar ataxia (SCA) is an autosomal dominant neurodegenerative disease (ND)
with a high mortality rate. Symptomatic treatment is the only clinically adopted treatment …

Animal models of human neurological disorders provide valuable experimental tools which
enable us to study various aspects of disorder pathogeneses, ranging from structural …

Polyglutamine disorders are a complex group of incurable neurodegenerative disorders
caused by an abnormal expansion in the trinucleotide cytosine-adenine-guanine tract of the …

Many patients with spinocerebellar ataxia (SCA) suffer from diverse neuropsychiatric issues,
including memory impairments, apathy, depression, or anxiety. These neuropsychiatric …

The use of induced pluripotent stem cells (iPSCs) is a promising approach when used as
models to study neurodegenerative disorders (NDDs) in vitro. iPSCs have been used in in …

The shaker rat carries a naturally occurring mutation leading to progressive ataxia
characterized by Purkinje cell (PC) loss. We previously reported on fine-mapping the shaker …

Degenerative effects of nerve tissues are often accompanied by changes in vascularization.
In this regard, knowledge about hereditary cerebellar degeneration is limited. In this study …