Type 2 chronic inflammatory diseases: targets, therapies and unmet needs

P Kolkhir, CA Akdis, M Akdis, C Bachert… - Nature Reviews Drug …, 2023 - nature.com
Over the past two decades, significant progress in understanding of the pathogenesis of type
2 chronic inflammatory diseases has enabled the identification of compounds for more than …

The role of TSLP in atopic dermatitis: from pathogenetic molecule to therapeutical target

J Luo, Z Zhu, Y Zhai, J Zeng, L Li… - Mediators of …, 2023 - Wiley Online Library
Atopic dermatitis (AD) is a kind of chronic skin disease with inflammatory infiltration,
characterized by skin barrier dysfunction, immune response dysregulation, and skin …

[HTML][HTML] The immunological and structural epidermal barrier dysfunction and skin microbiome in atopic dermatitis-an update

T Çetinarslan, L Kümper… - Frontiers in Molecular …, 2023 - frontiersin.org
Atopic dermatitis (AD) is a common, chronic and relapsing inflammatory skin disease with
various clinical presentations and combinations of symptoms. The pathophysiology of AD is …

[HTML][HTML] Cytokines and epidermal lipid abnormalities in atopic dermatitis: a systematic review

PR Upadhyay, L Seminario-Vidal, B Abe, C Ghobadi… - Cells, 2023 - mdpi.com
Atopic dermatitis (AD) is the most common chronic inflammatory skin disease and presents a
major public health problem worldwide. It is characterized by a recurrent and/or chronic …

[HTML][HTML] Alpha-Mangostin: A Potent Inhibitor of TRPV3 and Pro-Inflammatory Cytokine Secretion in Keratinocytes

TH Dang, JY Kim, HJ Kim, BJ Kim, WK Kim… - International Journal of …, 2023 - mdpi.com
The TRPV3 calcium ion channel is vital for maintaining skin health and has been associated
with various skin-related disorders. Since TRPV3 is involved in the development of skin …

Preclinical study models of psoriasis: State-of-the-art techniques for testing pharmaceutical products in animal and nonanimal models

K Yadav, D Singh, MR Singh, S Minz… - International …, 2023 - Elsevier
Local and systemic treatments exist for psoriasis, but none can do more than control its
symptoms because of its numerous unknown mechanisms. The lack of validated testing …

[HTML][HTML] Hydrolyzed collagen induces an anti-inflammatory response that induces proliferation of skin fibroblast and keratinocytes

MAR Brandao-Rangel, CR Oliveira… - Nutrients, 2022 - mdpi.com
Collagen-based products are found in different pharmaceuticals, medicine, food, and
cosmetics products for a wide variety of applications. However, its use to prevent or improve …

[HTML][HTML] Therapeutic effects of mesenchymal stem cells and their derivatives in common skin inflammatory diseases: Atopic dermatitis and psoriasis

J Yang, M Xiao, K Ma, H Li, M Ran, S Yang… - Frontiers in …, 2023 - frontiersin.org
Chronic skin inflammatory diseases including atopic dermatitis (AD) and psoriasis have
been considered uncontrolled inflammatory responses, which have usually troubled patients …

Advanced In Vitro Three-Dimensional Skin Models of Atopic Dermatitis

HJ Jang, JB Lee, JK Yoon - Tissue Engineering and Regenerative …, 2023 - Springer
Atopic dermatitis (AD) is one of the most prevalent inflammatory skin diseases that is
characterized by eczematous rashes, intense itching, dry skin, and sensitive skin. Although …

[HTML][HTML] Claudin-1 mediated tight junction dysfunction as a contributor to atopic march

Y Xia, H Cao, J Zheng, L Chen - Frontiers in Immunology, 2022 - frontiersin.org
Atopic march refers to the phenomenon wherein the occurrence of asthma and food allergy
tends to increase after atopic dermatitis. The mechanism underlying the progression of …