Translational applications of hydrogels
Advances in hydrogel technology have unlocked unique and valuable capabilities that are
being applied to a diverse set of translational applications. Hydrogels perform functions …
being applied to a diverse set of translational applications. Hydrogels perform functions …
Cytokine-mediated communication: a quantitative appraisal of immune complexity
G Altan-Bonnet, R Mukherjee - Nature Reviews Immunology, 2019 - nature.com
Intercellular communication mediated by cytokines is the main mechanism by which cells of
the immune system talk to each other. Many aspects of cytokine signalling in the immune …
the immune system talk to each other. Many aspects of cytokine signalling in the immune …
Synthetic cytokine circuits that drive T cells into immune-excluded tumors
Chimeric antigen receptor (CAR) T cells are ineffective against solid tumors with
immunosuppressive microenvironments. To overcome suppression, we engineered circuits …
immunosuppressive microenvironments. To overcome suppression, we engineered circuits …
[HTML][HTML] Macrophage spatial heterogeneity in gastric cancer defined by multiplex immunohistochemistry
YK Huang, M Wang, Y Sun, N Di Costanzo… - Nature …, 2019 - nature.com
Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune
components in gastric cancer (GC), are difficult to characterize due to their heterogeneity …
components in gastric cancer (GC), are difficult to characterize due to their heterogeneity …
Interleukin-23 engineering improves CAR T cell function in solid tumors
Cytokines that stimulate T cell proliferation, such as interleukin (IL)-15, have been explored
as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells …
as a means of boosting the antitumor activity of chimeric antigen receptor (CAR) T cells …
[HTML][HTML] A local regulatory T cell feedback circuit maintains immune homeostasis by pruning self-activated T cells
A fraction of mature T cells can be activated by peripheral self-antigens, potentially eliciting
host autoimmunity. We investigated homeostatic control of self-activated T cells within …
host autoimmunity. We investigated homeostatic control of self-activated T cells within …
Spatially distinct reprogramming of the tumor microenvironment based on tumor invasion in diffuse-type gastric cancers
HY Jeong, IH Ham, SH Lee, D Ryu, SY Son… - Clinical Cancer …, 2021 - AACR
Purpose: Histologic features of diffuse-type gastric cancer indicate that the tumor
microenvironment (TME) may substantially impact tumor invasiveness. However, cellular …
microenvironment (TME) may substantially impact tumor invasiveness. However, cellular …
Next-generation computational tools for interrogating cancer immunity
The remarkable success of cancer therapies with immune checkpoint blockers is
revolutionizing oncology and has sparked intensive basic and translational research into the …
revolutionizing oncology and has sparked intensive basic and translational research into the …
High-resolution imaging of cellular dopamine efflux using a fluorescent nanosensor array
Intercellular communication via chemical signaling proceeds with both spatial and temporal
components, but analytical tools, such as microfabricated electrodes, have been limited to …
components, but analytical tools, such as microfabricated electrodes, have been limited to …
[HTML][HTML] A tunable diffusion-consumption mechanism of cytokine propagation enables plasticity in cell-to-cell communication in the immune system
Immune cells communicate by exchanging cytokines to achieve a context-appropriate
response, but the distances over which such communication happens are not known. Here …
response, but the distances over which such communication happens are not known. Here …