Repurposing of the Nootropic Drug Vinpocetine as an Analgesic and Anti‐Inflammatory Agent: Evidence in a Mouse Model of Superoxide Anion‐Triggered …
Y Lourenco-Gonzalez, V Fattori… - Mediators of …, 2019 - Wiley Online Library
Clinically active drugs for the treatment of acute pain have their prescription limited due to
the significant side effects they induce. An increase in reactive oxygen species (ROS) has …
the significant side effects they induce. An increase in reactive oxygen species (ROS) has …
The effect of agomelatine treatment on diabetes-induced cognitive impairments in rats: concomitant alterations in the hippocampal neuron numbers
ÖD Can, Uİ Üçel, Ü Demir Özkay… - International Journal of …, 2018 - mdpi.com
Researches that are related to the central nervous system complications of diabetes have
indicated higher incidence of cognitive disorders in patients. Since the variety of nootropic …
indicated higher incidence of cognitive disorders in patients. Since the variety of nootropic …
Effect of melatonin and resveratrol against memory impairment and hippocampal damage in a rat model of vascular dementia
D Shen, X Tian, W Sang, R Song - Neuroimmunomodulation, 2017 - karger.com
Objectives: This study was intended to investigate whether treatment with resveratrol and
melatonin alone or in combination can exert neurorestorative effects in a rat model of …
melatonin alone or in combination can exert neurorestorative effects in a rat model of …
[HTML][HTML] Discovery of novel phosphodiesterase-1 inhibitors for curing vascular dementia: Suppression of neuroinflammation by blocking NF-κB transcription regulation …
Q Zhou, M Le, Y Yang, W Wang, Y Huang… - … Pharmaceutica Sinica B, 2023 - Elsevier
Vascular dementia (VaD) is the second commonest type of dementia which lacks of efficient
treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is …
treatments currently. Neuroinflammation as a prominent pathological feature of VaD, is …
Agomelatine protects heart and aorta against lipopolysaccharide-induced cardiovascular toxicity via inhibition of NF-kβ phosphorylation
The aim of this study was to investigate the possible ameliorating effects of agomelatine
(AGO) on lipopolysaccharide (LPS)-induced endothelial and cardiac damage. Twenty-four …
(AGO) on lipopolysaccharide (LPS)-induced endothelial and cardiac damage. Twenty-four …
Papaverine ameliorates prenatal alcohol‐induced experimental attention deficit hyperactivity disorder by regulating neuronal function, inflammation, and oxidative …
Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with
complex aetiology and phenotypes. Phosphodiesterase10A (PDE10A) has been shown to …
complex aetiology and phenotypes. Phosphodiesterase10A (PDE10A) has been shown to …
Combination of vinpocetine and dexamethasone alleviates cognitive impairment in nasopharyngeal carcinoma patients following radiation injury
P Zhang, Y Cao, S Chen, L Shao - Pharmacology, 2021 - karger.com
Background: Nasopharyngeal carcinoma (NPC) originates in the nasopharyngeal
epithelium. The most common treatments for NPC rT1–4 are radiotherapy and surgery. The …
epithelium. The most common treatments for NPC rT1–4 are radiotherapy and surgery. The …
Reversal in cognition impairments, cholinergic dysfunction, and cerebral oxidative stress through the modulation of ryanodine receptors (RyRs) and cysteinyl …
P Singh, B Sharma - Current neurovascular research, 2016 - ingentaconnect.com
Chronic cerebral hypoperfusion (CCH) is a general pathophysiological condition occurring
in vascular dementia (VaD) associated with negative impact on cognitive functions …
in vascular dementia (VaD) associated with negative impact on cognitive functions …
Neuroprotective effects of nicorandil in chronic cerebral hypoperfusion-induced vascular dementia
Background Ischemia-induced chronic cerebral hypoperfusion (CCH) is associated with
reduced cerebral blood flow and vascular dementia (VaD). Brain mitochondrial potassium …
reduced cerebral blood flow and vascular dementia (VaD). Brain mitochondrial potassium …
Agomelatine's effect on circadian locomotor rhythm alteration and depressive-like behavior in 6-OHDA lesioned rats
LC Souza, BJ Martynhak, TB Bassani, JM Turnes… - Physiology & …, 2018 - Elsevier
Parkinson's disease (PD) patients often suffer from circadian locomotor rhythms impairment
and depression, important non-motor symptoms. It is known that toxin-based animal models …
and depression, important non-motor symptoms. It is known that toxin-based animal models …