Superoxide dismutases (SODs) are metalloenzymes that play a major role in antioxidant
defense against oxidative stress in the body. SOD supplementation may therefore trigger the …

Abstract Endothelin-1 (ET-1) is a potent endogenous vasoconstrictor, mainly secreted by
endothelial cells. It acts through two types of receptors: ETA and ETB. Apart from a …

Cardiovascular diseases are a leading cause of morbidity and mortality in most developed
countries of the world. Pharmaceuticals, illicit drugs, and toxins can significantly contribute to …

Mitochondrial biology has seen a surge in popularity in the past 5 years, with the emergence
of numerous new avenues of exciting mitochondria-related research including …

Background—Pulmonary arterial hypertension (PAH) is associated with sustained
inflammation known to promote DNA damage. Despite these unfavorable environmental …

Pulmonary arterial hypertension (PAH) is responsible for the premature death mainly
because of progressive and severe heart failure. This disease is characterized by increased …

The endothelin axis, recognized for its vasoconstrictive action, plays a central role in the
pathology of pulmonary arterial hypertension (PAH). Treatment with approved endothelin …

Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left
untreated rapidly progresses to right ventricular failure and eventually death. In the quest to …

Pulmonary arterial hypertension (PAH) is a progressive and fatal lung disease of
multifactorial etiology. Most of the available drugs and FDA-approved therapies for treating …

Pulmonary arterial hypertension (PAH) is a devastating disease with poor prognosis and
limited therapeutic options. We screened for pathways that may be responsible for the …