Definition and signatures of lung fibroblast populations in development and fibrosis in mice and men
The heterogeneity of fibroblasts in the murine and human lung during homeostasis and
disease is increasingly recognized. It remains unclear if the different phenotypes identified to …
disease is increasingly recognized. It remains unclear if the different phenotypes identified to …
Expression of syndecan-1 in chronic liver diseases: Correlation with hepatic fibrosis
A Charchanti, P Kanavaros, E Koniaris, A Kataki… - in vivo, 2021 - iv.iiarjournals.org
Background/Aim: The mechanisms underlying the contribution of the heparan sulfate
proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as …
proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as …
Recent advances in molecular diagnosis of pulmonary fibrosis for precision medicine
Pulmonary fibrosis is a serious, progressive lung disease characterized by scarring and
stiffening lung tissues, affecting the respiratory system and leading to organ failure. It is a …
stiffening lung tissues, affecting the respiratory system and leading to organ failure. It is a …
Molecular Endotypes of Idiopathic Pulmonary Fibrosis: A Latent Class Analysis of Two Multicenter Observational Cohorts
MV Maddali, AR Moore, P Sinha… - American Journal of …, 2024 - atsjournals.org
Rationale: Idiopathic pulmonary fibrosis (IPF) causes irreversible fibrosis of the lung
parenchyma. While antifibrotic therapy can slow IPF progression, treatment response is …
parenchyma. While antifibrotic therapy can slow IPF progression, treatment response is …
The clinical manifestations and molecular pathogenesis of radiation fibrosis
Advances in radiation techniques have enabled the precise delivery of higher doses of
radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the …
radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the …
Temporo-spatial cellular atlas of the regenerating alveolar niche in idiopathic pulmonary fibrosis
Healthy repair of the alveoli requires alveolar stem cells to differentiate into cells designed
for gas exchange. In chronic lung fibrotic disease like idiopathic pulmonary fibrosis (IPF) …
for gas exchange. In chronic lung fibrotic disease like idiopathic pulmonary fibrosis (IPF) …
Transcriptomic profiling in canines and humans reveals cancer specific gene modules and biological mechanisms common to both species
GJ Tawa, J Braisted, D Gerhold, G Grewal… - PLoS Computational …, 2021 - journals.plos.org
Understanding relationships between spontaneous cancer in companion (pet) canines and
humans can facilitate biomarker and drug development in both species. Towards this end …
humans can facilitate biomarker and drug development in both species. Towards this end …
Current and prospective applications of exosomal microRNAs in pulmonary fibrosis
T Yang, J Wang, J Zhao, Y Liu - … Journal of Molecular …, 2022 - spandidos-publications.com
Pulmonary fibrosis (PF) is a chronic, progressive, irreversible and life‑threatening lung
disease. However, the pathogenesis and molecular mechanisms of this condition remain …
disease. However, the pathogenesis and molecular mechanisms of this condition remain …
Single-cell transcriptomics of hepatic stellate cells uncover crucial pathways and key regulators involved in non-alcoholic steatohepatitis
W He, C Huang, X Shi, M Wu, H Li, Q Liu… - Endocrine …, 2023 - ec.bioscientifica.com
Background Fibrosis is an important pathological process in the development of non-
alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central …
alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central …
Pathogenesis of fibrosis in interstitial lung disease
O Burgy, PS Bellaye, G Beltramo… - Current Opinion in …, 2020 - journals.lww.com
This review emphasizes the contribution of different cell types and mechanisms during
pulmonary fibrosis, highlights new insights for identification of potential therapeutic …
pulmonary fibrosis, highlights new insights for identification of potential therapeutic …