The heterogeneity of fibroblasts in the murine and human lung during homeostasis and
disease is increasingly recognized. It remains unclear if the different phenotypes identified to …

Background/Aim: The mechanisms underlying the contribution of the heparan sulfate
proteoglycan syndecan-1 to liver tissue injury and to crucial biological processes, such as …

Pulmonary fibrosis is a serious, progressive lung disease characterized by scarring and
stiffening lung tissues, affecting the respiratory system and leading to organ failure. It is a …

Rationale: Idiopathic pulmonary fibrosis (IPF) causes irreversible fibrosis of the lung
parenchyma. While antifibrotic therapy can slow IPF progression, treatment response is …

Advances in radiation techniques have enabled the precise delivery of higher doses of
radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the …

Healthy repair of the alveoli requires alveolar stem cells to differentiate into cells designed
for gas exchange. In chronic lung fibrotic disease like idiopathic pulmonary fibrosis (IPF) …

Understanding relationships between spontaneous cancer in companion (pet) canines and
humans can facilitate biomarker and drug development in both species. Towards this end …

Pulmonary fibrosis (PF) is a chronic, progressive, irreversible and life‑threatening lung
disease. However, the pathogenesis and molecular mechanisms of this condition remain …

Background Fibrosis is an important pathological process in the development of non-
alcoholic steatohepatitis (NASH), and the activation of hepatic stellate cell (HSC) is a central …

This review emphasizes the contribution of different cell types and mechanisms during
pulmonary fibrosis, highlights new insights for identification of potential therapeutic …