Therapeutic potential and pharmaceutical development of a multitargeted flavonoid phloretin

KT Nakhate, H Badwaik, R Choudhary, K Sakure… - Nutrients, 2022 - mdpi.com
Phloretin is a flavonoid of the dihydrogen chalcone class, present abundantly in apples and
strawberries. The beneficial effects of phloretin are mainly associated with its potent …

Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats

SP Kamdi, HR Badwaik, A Raval, KT Nakhate - European Journal of …, 2021 - Elsevier
Diabetes associated oxidative stress and impaired cholinergic neurotransmission causes
cognitive deficits. Although phloridzin shows antioxidant-and insulin sensitizing-activities, its …

Ameliorative Effect of Ocimum forskolei Benth on Diabetic, Apoptotic, and Adipogenic Biomarkers of Diabetic Rats and 3T3-L1 Fibroblasts Assisted by In Silico …

HE Khalil, MF Abdelwahab, PM Emeka… - Molecules, 2022 - mdpi.com
Diabetes mellitus (DM) is a complicated condition that is accompanied by a plethora of
metabolic symptoms, including disturbed serum glucose and lipid profiles. Several herbs are …

Echinops spinosus effect against diabetes and its hepatorenal complications: total extract and flavonoids fraction

MS Othman, AM Khaled, AH Al-Bagawi… - … Science and Pollution …, 2022 - Springer
The perennial plant Echinops spinosus (ES) grows in the Hail area of Saudi Arabia, and its
traditional formulations are often employed in folk medicine. The goal of this study is to …

[HTML][HTML] Anti-diabetic activity of aqueous extract of Trichilia prieureana A. Juss leaves in fructose-fed streptozotocin-induced diabetic male Wistar rats

OA Ojo, MT Yakubu - Journal of Traditional and Complementary Medicine, 2024 - Elsevier
Background and aim Ethanolic extract of Trichilia prieureana leaves have been reported to
exhibit anti-hyperglycemic activities without detailed information on the anti-diabetic …

[HTML][HTML] Dual actions of gallic acid and andrographolide trigger AdipoR1 to stimulate insulin secretion in a streptozotocin-induced diabetes rat model

TS Wong, FM Tap, Z Hashim, FAA Majid… - Journal of Traditional …, 2023 - Elsevier
Common treatments for the management of diabetes have limitations due to side effects,
hence the need for continuous research to discover new remedies with better therapeutic …

Sungkai Leaves (Peronema Canescens) Ameliorates the Plasma Glucose Profile and the Pancreatic Histopathological Regeneration of Diabetic Wistar Rats

D Primal, R Ahriyasna, R Yanti - Jurnal Keperawatan Silampari, 2024 - journal.ipm2kpe.or.id
This study aims to test how effective oral infusion of sungkai leaves is on the profile of
changes in blood plasma glucose levels and regeneration of pancreatic tissue in diabetic …

Phyto-complexed systems as a versatile tool for the delivery of plant-based drugs

M Baghel, P Yadav, H Badwaik, K Nakhate - … and Herbal Drugs, 2023 - Elsevier
Plant-based drugs have attracted a lot of attention because of their broad therapeutic
qualities and specificity as medicines, nutraceuticals, and functional foods in human health …

Asparagus gonoclados Baker (AGAF) Root Tubers Improve Glycemic Control and Hyperlipidemia in Streptozotocin-Induced Diabetic Rats

A Rajasekhar, K Peddanna, N Vedasree… - Journal of Biologically …, 2023 - Taylor & Francis
This study aimed to investigate the antidiabetic and antihyperlipidemic activity of the active
fraction of Asparagus gonoclados root tubers (AGAF) in streptozotocin-induced diabetic rats …

Impact of phytomedicines and their novel delivery systems as an alternative for the treatment of neurodegenerative disorders

K Nakhate, S Mangrulkar, H Badwaik… - … and Herbal Drugs, 2023 - Elsevier
Neurodegenerative disorders (NDs) such as Alzheimer disease and Parkinson disease
pose a serious health challenge as their progression can only be slowed down by the …