Antigen processing and presentation
F Kotsias, I Cebrian, A Alloatti - International review of cell and molecular …, 2019 - Elsevier
Dendritic cells are at the center of immune responses. They are defined by their ability to
sense the environment, take up and process antigen, migrate to secondary lymphoid …
sense the environment, take up and process antigen, migrate to secondary lymphoid …
The biology and underlying mechanisms of cross-presentation of exogenous antigens on MHC-I molecules
To monitor the health of cells, the immune system tasks antigen-presenting cells with
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …
gathering antigens from other cells and bringing them to CD8 T cells in the form of peptides …
Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells
Tumours have developed strategies to interfere with most steps required for anti-tumour
immune responses. Although many populations contribute to anti-tumour responses, tumour …
immune responses. Although many populations contribute to anti-tumour responses, tumour …
Oxidized lipids block antigen cross-presentation by dendritic cells in cancer
W Cao, R Ramakrishnan, VA Tuyrin… - The Journal of …, 2014 - journals.aai.org
Cross-presentation is one of the main features of dendritic cells (DCs), which is critically
important for the development of spontaneous and therapy-inducible antitumor immune …
important for the development of spontaneous and therapy-inducible antitumor immune …
BRAFV600E Co-opts a Conserved MHC Class I Internalization Pathway to Diminish Antigen Presentation and CD8+ T-cell Recognition of Melanoma
SD Bradley, Z Chen, B Melendez, A Talukder… - Cancer immunology …, 2015 - AACR
Oncogene activation in tumor cells induces broad and complex cellular changes that
contribute significantly to disease initiation and progression. In melanoma, oncogenic …
contribute significantly to disease initiation and progression. In melanoma, oncogenic …
[HTML][HTML] STING, DCs and the link between innate and adaptive tumor immunity
RE Vatner, EM Janssen - Molecular immunology, 2019 - Elsevier
Cancer and the immune system are intimately related. Much of the bulk of tumors is
comprised of stromal leukocytes with immune functions, which serve to both promote and …
comprised of stromal leukocytes with immune functions, which serve to both promote and …
A CD74-dependent MHC class I endolysosomal cross-presentation pathway
G Basha, K Omilusik, A Chavez-Steenbock… - Nature …, 2012 - nature.com
Immune responses are initiated and primed by dendritic cells (DCs) that cross-present
exogenous antigen. The chaperone CD74 (invariant chain) is thought to promote DC …
exogenous antigen. The chaperone CD74 (invariant chain) is thought to promote DC …
Human dendritic cells in cancer
E Kvedaraite, F Ginhoux - Science immunology, 2022 - science.org
Dendritic cells (DCs) are professional antigen-presenting cells, orchestrating innate and
adaptive immunity during infections, autoimmune diseases, and malignancies. Since the …
adaptive immunity during infections, autoimmune diseases, and malignancies. Since the …
IFN-α enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing
Cross-presentation allows antigen-presenting cells to present exogenous antigens to CD8+
T cells, playing an essential role in controlling infections and tumor development. IFN-α …
T cells, playing an essential role in controlling infections and tumor development. IFN-α …
Cross-presentation in mouse and human dendritic cells
E Segura, S Amigorena - Advances in immunology, 2015 - Elsevier
Cross-presentation designates the presentation of exogenous antigens on major
histocompatibility complex class I molecules and is essential for the initiation of cytotoxic …
histocompatibility complex class I molecules and is essential for the initiation of cytotoxic …