Non-alcoholic fatty liver disease: metabolic, genetic, epigenetic and environmental risk factors

O Juanola, S Martínez-López, R Francés… - International journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is one of the most frequent causes of chronic liver
disease in the Western world, probably due to the growing prevalence of obesity, metabolic …

Epigenetics of aging and aging-associated diseases

D Saul, RL Kosinsky - International journal of molecular sciences, 2021 - mdpi.com
Aging represents the multifactorial decline in physiological function of every living organism.
Over the past decades, several hallmarks of aging have been defined, including epigenetic …

Current options and future directions for NAFLD and NASH treatment

C Zhang, M Yang - International Journal of Molecular Sciences, 2021 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease
worldwide, with a broad spectrum ranging from simple steatosis to advanced stage of …

Diagnostic modalities of non-alcoholic fatty liver disease: from biochemical biomarkers to multi-omics non-invasive approaches

E Martinou, M Pericleous, I Stefanova, V Kaur… - Diagnostics, 2022 - mdpi.com
Non-Alcoholic Fatty Liver Disease (NAFLD) is currently the most common cause of chronic
liver disease worldwide, and its prevalence is increasing globally. NAFLD is a multifaceted …

Epigenetic regulation of energy metabolism in obesity

W Gao, JL Liu, X Lu, Q Yang - Journal of molecular cell biology, 2021 - academic.oup.com
Obesity has reached epidemic proportions globally. Although modern adoption of a
sedentary lifestyle coupled with energy-dense nutrition is considered to be the main cause …

Faecal Microbiota transplantation affects liver DNA methylation in Non-alcoholic fatty liver disease: a multi-omics approach

D Stols-Gonçalves, AL Mak, MS Madsen… - Gut …, 2023 - Taylor & Francis
Individuals with nonalcoholic fatty liver disease (NAFLD) have an altered gut microbiota
composition. Moreover, hepatic DNA methylation may be altered in the state of NAFLD …

DNA 5mC and RNA m6A modification successively facilitates the initiation and perpetuation stages of HSC activation in liver fibrosis progression

Y Feng, S Guo, Y Zhao, H Dong, J Qian, Y Hu… - Cell Death & …, 2023 - nature.com
Hepatic stellate cells (HSC) are key effector cells in liver fibrosis. Upon stimulation, the
quiescent HSC undergoes complex morphological and functional changes to …

Detangling the interrelations between MAFLD, insulin resistance, and key hormones

SC Pal, M Eslam, N Mendez-Sanchez - Hormones, 2022 - Springer
Metabolic dysfunction–associated fatty liver disease (MAFLD) has increasingly become a
significant and highly prevalent cause of chronic liver disease, displaying a wide array of risk …

Epigenetic regulation of hepatic lipid metabolism by DNA methylation

S Wang, L Zha, X Cui, YT Yeh, R Liu, J Jing… - Advanced …, 2023 - Wiley Online Library
While extensive investigations have been devoted to the study of genetic pathways related
to fatty liver diseases, much less is known about epigenetic mechanisms underlying these …

Epigenetic regulation of peroxisome proliferator-activated receptor gamma mediates high-fat diet-induced non-alcoholic fatty liver disease

T Hajri, M Zaiou, TV Fungwe, K Ouguerram, S Besong - Cells, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in Western countries and has
become a serious public health concern. Although Western-style dietary patterns …