Cardioimmunology: the immune system in cardiac homeostasis and disease

FK Swirski, M Nahrendorf - Nature Reviews Immunology, 2018 - nature.com
The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …

Cardiac fibrosis: the fibroblast awakens

JG Travers, FA Kamal, J Robbins, KE Yutzey… - Circulation …, 2016 - Am Heart Assoc
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …

Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation

C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …

Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation

S Nattel - JACC: Clinical Electrophysiology, 2017 - jacc.org
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …

The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms

J Andrade, P Khairy, D Dobrev, S Nattel - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …

Atrial remodeling and atrial fibrillation: recent advances and translational perspectives

S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …

Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression

J Heijman, N Voigt, S Nattel, D Dobrev - Circulation research, 2014 - Am Heart Assoc
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Atrial fibrillation pathophysiology: implications for management

Y Iwasaki, K Nishida, T Kato, S Nattel - Circulation, 2011 - Am Heart Assoc
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important
contributor to population morbidity and mortality. An arrhythmia that is particularly common …

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

KT Weber, Y Sun, SK Bhattacharya… - Nature Reviews …, 2013 - nature.com
The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …

Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model

E Guasch, B Benito, X Qi, C Cifelli, P Naud… - Journal of the American …, 2013 - jacc.org
Objectives: The goal of this study was to assess mechanisms underlying atrial fibrillation
(AF) promotion by exercise training in an animal model. Background: High-level exercise …