Cardioimmunology: the immune system in cardiac homeostasis and disease
FK Swirski, M Nahrendorf - Nature Reviews Immunology, 2018 - nature.com
The past few decades have generated growing recognition that the immune system makes
an important contribution to cardiac development, composition and function. Immune cells …
an important contribution to cardiac development, composition and function. Immune cells …
Cardiac fibrosis: the fibroblast awakens
Myocardial fibrosis is a significant global health problem associated with nearly all forms of
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
heart disease. Cardiac fibroblasts comprise an essential cell type in the heart that is …
Enhanced cardiomyocyte NLRP3 inflammasome signaling promotes atrial fibrillation
C Yao, T Veleva, L Scott Jr, S Cao, L Li, G Chen… - Circulation, 2018 - Am Heart Assoc
Background: Atrial fibrillation (AF) is frequently associated with enhanced inflammatory
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
response. The NLRP3 (NACHT, LRR, and PYD domain containing protein 3) inflammasome …
Molecular and cellular mechanisms of atrial fibrosis in atrial fibrillation
S Nattel - JACC: Clinical Electrophysiology, 2017 - jacc.org
Atrial fibrillation (AF) is the most common arrhythmia in clinical practice. Atrial fibrosis has
emerged as an important pathophysiological contributor and has been linked to AF …
emerged as an important pathophysiological contributor and has been linked to AF …
The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms
Atrial fibrillation (AF) is the most common arrhythmia (estimated lifetime risk, 22%–26%). The
aim of this article is to review the clinical epidemiological features of AF and to relate them to …
aim of this article is to review the clinical epidemiological features of AF and to relate them to …
Atrial remodeling and atrial fibrillation: recent advances and translational perspectives
S Nattel, M Harada - Journal of the American College of Cardiology, 2014 - jacc.org
Atrial fibrillation (AF) is the most common sustained arrhythmia in clinical practice. AF and its
complications are responsible for important population morbidity and mortality. Presently …
complications are responsible for important population morbidity and mortality. Presently …
Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
Atrial fibrillation pathophysiology: implications for management
Y Iwasaki, K Nishida, T Kato, S Nattel - Circulation, 2011 - Am Heart Assoc
Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is an important
contributor to population morbidity and mortality. An arrhythmia that is particularly common …
contributor to population morbidity and mortality. An arrhythmia that is particularly common …
Myofibroblast-mediated mechanisms of pathological remodelling of the heart
KT Weber, Y Sun, SK Bhattacharya… - Nature Reviews …, 2013 - nature.com
The syncytium of cardiomyocytes in the heart is tethered within a matrix composed
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …
principally of type I fibrillar collagen. The matrix has diverse mechanical functions that …
Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model
E Guasch, B Benito, X Qi, C Cifelli, P Naud… - Journal of the American …, 2013 - jacc.org
Objectives: The goal of this study was to assess mechanisms underlying atrial fibrillation
(AF) promotion by exercise training in an animal model. Background: High-level exercise …
(AF) promotion by exercise training in an animal model. Background: High-level exercise …