[HTML][HTML] Prevention of atrial fibrillation after open-chest surgery with extracellular vesicle therapy

S Parent, R Vaka, Y Risha, C Ngo, P Kanda, S Nattel… - JCI insight, 2023 - ncbi.nlm.nih.gov
Almost half of patients recovering from open-chest surgery experience atrial fibrillation (AF)
that results principally from inflammation in the pericardial space surrounding the heart …

Novel molecular targets for atrial fibrillation therapy

D Dobrev, L Carlsson, S Nattel - Nature reviews Drug discovery, 2012 - nature.com
Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for
substantial morbidity and mortality in the general population. Current treatments have …

The correlation between gut microbiome and atrial fibrillation: pathophysiology and therapeutic perspectives

N Li, L Wang, L Li, MZ Yang, QX Wang, XW Bai… - Military Medical …, 2023 - Springer
Regulation of gut microbiota and its impact on human health is the theme of intensive
research. The incidence and prevalence of atrial fibrillation (AF) are continuously escalating …

Inflammatory pathways underlying atrial fibrillation

K Friedrichs, A Klinke, S Baldus - Trends in molecular medicine, 2011 - cell.com
The pathophysiology of atrial fibrillation (AF) remains incompletely understood, despite its
prevalence and contributing role in stroke and heart failure. Whereas previous studies have …

In vivo optophysiology reveals that G-protein activation triggers osmotic swelling and increased light scattering of rod photoreceptors

P Zhang, RJ Zawadzki, M Goswami… - Proceedings of the …, 2017 - National Acad Sciences
The light responses of rod and cone photoreceptors have been studied
electrophysiologically for decades, largely with ex vivo approaches that disrupt the …

Glucose fluctuations increase the incidence of atrial fibrillation in diabetic rats

S Saito, Y Teshima, A Fukui, H Kondo… - Cardiovascular …, 2014 - academic.oup.com
Aims We investigated whether glucose fluctuations aggravate cardiac fibrosis and increase
the occurrence of atrial fibrillation (AF) in rats with diabetes mellitus (DM). Methods and …

Arrhythmogenic implications of fibroblast-myocyte interactions

S Rohr - Circulation: Arrhythmia and Electrophysiology, 2012 - Am Heart Assoc
With increasing life span as afforded by nutritional, technological, and therapeutic
advancements during the last century, cardiac diseases have moved to the top of morbidity …

Gasotransmitters: potential therapeutic molecules of fibrotic diseases

Y Chen, S Yuan, Y Cao, G Kong, F Jiang… - Oxidative Medicine …, 2021 - Wiley Online Library
Fibrosis is defined as the pathological progress of excessive extracellular matrix (ECM),
such as collagen, fibronectin, and elastin deposition, as the regenerative capacity of cells …

Origin, development, and differentiation of cardiac fibroblasts

JD Lajiness, SJ Conway - Journal of molecular and cellular cardiology, 2014 - Elsevier
Cardiac fibroblasts are the most abundant cell in the mammalian heart. While they have
been historically underappreciated in terms of their functional contributions to cardiac …

MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential

M Harada, X Luo, T Murohara, B Yang… - Circulation …, 2014 - Am Heart Assoc
MicroRNAs (miRNAs) are emerging as key control molecules in the regulation of gene
expression, and their role in heart disease is becoming increasingly evident. Given the …