Innate immune cells, particularly macrophages and epithelial cells, play a key role in
multiple layers of immune responses. Alarmins and pro-inflammatory cytokines from the IL …

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology
that can affect nearly every organ system in the body. Besides genetic and environmental …

The aim of this study was to assess the change of IL-37 concentrations in rheumatoid
arthritis (RA) patients under Disease-modifying anti-rheumatic drug (DMARD) therapy, and …

Cytokines and chemokines produced by tubular epithelial and infiltrating cells are critical to
inflammation in renal ischemia–reperfusion injury. IL-37, a newly described IL-1 family …

Innate immune and inflammatory responses are involved in myocardial
ischaemia/reperfusion (I/R) injury. Interleukin (IL)-37 is a newly identified member of the IL-1 …

Background In models of COPD, environmental stressors induce innate immune responses,
inflammasome activation and inflammation. However, the interaction between these …

Recent research has widely investigated the anti-inflammatory effects of mesenchymal stem
cells and their secretory products, termed the secretome, in the treatment of multiple …

Autoimmune diseases (AIDs) are characterized by dysfunction and tissue destruction, and
recent studies have shown that interleukin (IL)‑37 expression is dysregulated in AIDs …

IL-37 was discovered as an anti-inflammatory and immunosuppressive cytokine of the IL-1
family. Significant advancements in the understanding of signaling pathways associated …

Interleukin‐37 (IL‐37) is an IL‐1 family cytokine discovered in recent years and has 5
different isoforms. As an immunosuppressive factor, IL‐37 can suppress excessive immune …