In the past decade, the small polyphenol resveratrol has received widespread attention as
either a potential therapy or as a preventive agent for numerous diseases. Studies using …

Sirtuins are a class of NAD+-dependent deacetylases having beneficial health effects. This
extensive review describes the numerous intracellular actions of the seven mammalian …

Accumulating evidence suggests that diet and lifestyle can play an important role in delaying
the onset or halting the progression of age‐related health disorders and to improve cognitive …

Sirtuin 1 (SIRT1) is an evolutionarily conserved NAD+-dependent deacetylase that is at the
pinnacle of metabolic control, all the way from yeast to humans. SIRT1 senses changes in …

Chronic inflammation is a major contributing factor in the pathogenesis of many age-
associated diseases. One central protein that regulates inflammation is NF-κB, the activity of …

The first link between sirtuins and longevity was made 15 years ago in yeast. These initial
studies sparked efforts by many laboratories working in diverse model organisms to …

Although the increased lifespan of our populations illustrates the success of modern
medicine, the risk of developing many diseases increases exponentially with old age …

Alzheimer's disease (AD) is a type of incurable neurodegenerative disease that is
characterized by the accumulation of amyloid-β (Aβ; plaques) and tau hyperphosphorylation …

Covering: up to the end of March 2012 Stilbenoids, a family of polyphenols known for the
complexity of their structure and for their diverse biological activities, occur with a limited but …

Epigenetic regulation, which includes changes in DNA methylation, histone modifications,
and alteration in microRNA (miRNA) expression without any change in the DNA sequence …