Our concept of a stable genome is evolving to one in which genomes are plastic and
responsive to environmental changes. Growing evidence shows that a variety of …

A basic principle of genetics is that the likelihood that a particular mutation occurs is
independent of its phenotypic consequences. The concept of adaptive mutation seemed to …

The evolutionary significance of stress-induced mutagenesis was evaluated by studying
mutagenesis in aging colonies (MAC) of Escherichia coli natural isolates. A large fraction of …

Genomic instability underlies many cancers and generates genetic variation that drives
cancer initiation, progression, and therapy resistance. In contrast with classical assumptions …

Deinococcus radiodurans, one of the most radioresistant organisms known to date, is able to
repair efficiently hundreds of DNA double-and single-strand breaks as well as other types of …

We have recently described the presence of a high proportion of Pseudomonas aeruginosa
isolates (20%) with an increased mutation frequency (mutators) in the lungs of cystic fibrosis …

Contrary to what was thought previously, bacteria seem to be, not merely spectators to their
own evolution, but, through a variety of mechanisms, able to increase the rate at which …

Mutation and subsequent recombination events create genetic diversity, which is subjected
to natural selection. Bacterial mismatch repair (MMR) deficient mutants, exhibiting high …

Mechanisms of evolution and evolution of antibiotic resistance are both fundamental and
world health problems. Stress-induced mutagenesis defines mechanisms of mutagenesis …

The inner workings of the cell require thousands of proteins, the blueprints for which reside
in the millions of DNA basepairs that comprise the genome. This DNA is subjected to a …