CD36 as a gatekeeper of myocardial lipid metabolism and therapeutic target for metabolic disease

JFC Glatz, LC Heather… - Physiological reviews, 2024 - journals.physiology.org
The multifunctional membrane glycoprotein CD36 is expressed in different types of cells and
plays a key regulatory role in cellular lipid metabolism, especially in cardiac muscle. CD36 …

Impact of immune cells in the tumor microenvironment of prostate cancer metastasis

JK Messex, GY Liou - Life, 2023 - mdpi.com
Prostate cancer is the most prevalent type of cancer in senior American men. Currently, the
five-year survival rate after the initial diagnosis of prostate cancer is close to 100 …

Targeting autophagy and lipid metabolism in cancer stem cells

B Chakravarti, JA Siddiqui, RA Sinha, S Raza - Biochemical pharmacology, 2023 - Elsevier
Cancer stem cells (CSCs) are a subset of cancer cells with self-renewal ability and tumor
initiating properties. Unlike the other non-stem cancer cells, CSCs resist traditional therapy …

[HTML][HTML] CD36 as a double-edged sword in cancer

M Jiang, R Karsenberg, F Bianchi, G van den Bogaart - Immunology Letters, 2023 - Elsevier
The membrane protein CD36 is a lipid transporter, scavenger receptor, and receptor for the
antiangiogenic protein thrombospondin 1 (TSP1). CD36 is expressed by cancer cells and by …

Mitochondria targeted drug delivery system overcoming drug resistance in intrahepatic cholangiocarcinoma by reprogramming lipid metabolism

Y Duan, M Deng, B Liu, X Meng, J Liao, Y Qiu, Z Wu… - Biomaterials, 2024 - Elsevier
The challenge of drug resistance in intrahepatic cholangiocarcinoma (ICC) is intricately
linked with lipid metabolism reprogramming. The hepatic lipase (HL) and the membrane …

Small-interfering RNA targeting proprotein convertase subtilisin/kexin type 9 might promote fatty liver disease and hepatocellular carcinoma through upregulation of …

FS Fan - Tumor Biology, 2023 - content.iospress.com
Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to low-density lipoprotein (LDL)
receptor and fatty acid translocase CD36, inducing lysosomal degradation of these two …

The function of CD36 in Mycobacterium tuberculosis infection

J Wang, H Cao, H Yang, N Wang, Y Weng… - Frontiers in …, 2024 - frontiersin.org
CD36 is a scavenger receptor that has been reported to function as a signaling receptor that
responds to pathogen-associated molecular patterns (PAMPs) and damage-associated …

[HTML][HTML] Melanoma-Derived Extracellular Vesicles Induce CD36-Mediated Pre-Metastatic Niche

S Suman, WK Nevala, AA Leontovich, C Ward… - Biomolecules, 2024 - mdpi.com
CD36 expression in both immune and non-immune cells is known to be directly involved in
cancer metastasis. Extracellular vesicles (EVs) secreted by malignant melanocytes play a …

Association between Novel Agents Targeting Proprotein Convertase Subtilisin/Kexin Type 9 and Cancer Incidence

HJ Lu, SI Wang, WS Huang, FS Fan, JCC Wei - Kexin Type - papers.ssrn.com
Background: Novel agents targeting proprotein convertase subtilisin/kexin type 9 (PCSK9)
effectively reduce the concentration of low-density lipoproteins. These agents mediating …