T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) …

To provide a T-cell population that will respond promptly to foreign antigen, the immune
system looks inward, using the variety of self-antigens to select and maintain a diverse …

Degradation of invariant chain (Ii) is a critical step in major histocompatibility complex class II–
restricted antigen presentation. Cathepsin L was found to be necessary for Ii degradation in …

Major histocompatibility complex (MHC) class II molecules acquire antigenic peptides after
degradation of the invariant chain (Ii), an MHC class II–associated protein that otherwise …

Positive selection to self-MHC/peptide complexes has long been viewed as a device for
skewing the T cell repertoire toward recognition of foreign peptides presented by self-MHC …

▪ Abstract Advances in gene technology have allowed the manipulation of molecular
interactions that shape the T cell repertoire. Although recognized as fundamental aspects of …

The rules for the conserved reaction of αβ T cell receptors (TCRs) with major
histocompatibility complex (MHC) proteins plus peptides are poorly understood, probably …

CD4+ 25+ T cells are a unique population of immunoregulatory T cells which are critical for
the prevention of autoimmunity. To address the thymic selection of these cells we have used …

Vertebrates express three cytokine-inducible proteasome subunits that are incorporated in
the place of their constitutively synthesized counterparts. There is increasing evidence that …

Through positive and negative selection, the thymus allows a small fraction of immature CD4
8 double positive thymocytes to differentiate into mature CD4 8 or CD4 8 single positive …