Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

Abstract The NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome is
a multiprotein complex involved in the release of mature interleukin-1β and triggering of …

Vascular complications of diabetes pose a severe threat to human health. Prevention and
treatment protocols based on a single vascular complication are no longer suitable for the …

Even in the absence of coronary artery disease and hypertension, diabetes mellitus (DM)
may increase the risk for heart failure development. This risk evolves from functional and …

Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …

Acute inflammation is a key component of the immune system's response to pathogens, toxic
agents, or tissue injury, involving the stimulation of defense mechanisms aimed to removing …

Linked to exacerbated inflammation, myocarditis is a cardiovascular disease, which may
lead to dilated cardiomyopathy. Although sex and age differences in the development of …

Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often
accompanied by severe cardiovascular complications (DCCs) as major causes of death in …

Highlights●H 2 S production was impaired in db/db mice and streptozotocin-induced
diabetic mice.●CSE knockout exacerbated diabetic cardiomyopathy in streptozotocin …

Cardiac fibrosis plays an essential role in the development of diastolic dysfunction and
contributes to heart failure with preserved ejection fraction (HFpEF). Our previous studies …