Processing of the NF-κB2 precursor protein p100 is a major step in noncanonical NF-κB
signaling. This signaling step requires the NF-κB inducing kinase (NIK) and its downstream …

Hypoxia and inflammation are coincidental events in a diverse range of disease states
including tumor growth, ischemia, and chronic inflammation. Hypoxia contributes to the …

There have been a number of recent discoveries relating to the functions of inhibitors of
apoptosis (IAPs) and TNF receptor-associated factors (TRAFs) in regulating signalling from …

Background DAVID syndrome is a rare condition combining anterior pituitary hormone
deficiency with common variable immunodeficiency. NFKB2 mutations have recently been …

Simple Summary The incidence of pancreatic cancer is increasing but there has been little
progress in the diagnosis and survival rates of this lethal cancer for decades. Understanding …

The transcription regulators of the NF-κB family have emerged as a critical factor affecting
the function of various adult tissues. The NF-κB family transcription factors are homo-and …

Mammalian signaling networks contain an abundance of negative feedback regulators that
may have overlapping (“fail-safe”) or specific functions. Within the NF-κB signaling module …

Many of the organ-specific autoimmune diseases affect endocrine organs. This is due to the
fact that the organ-specific autoantigens are often hormones or enzymes specifically …

Identifying immune correlates of protection and mechanisms of immunity accelerates and
streamlines the development of vaccines. RTS, S/AS01E, the most clinically advanced …

Abstract The oncogenic Epstein–Barr virus (EBV)-encoded latent infection membrane
protein 1 (LMP1) constitutively activates the 'canonical'NF-κB pathway that involves the …