The NLRP3 inflammasome is a crucial component of the innate immune system, playing a
pivotal role in initiating and regulating the body's inflammatory response to various …

A battery of proinflammatory agents triggers the activation of NF-κB. This inducible
transcription factor participates in the expression of an exceptionally large number of target …

Because elevated ubiquitin ligase atrogin‐1/MAFbx and MuRF1 mediate skeletal muscle
wasting associated with various catabolic conditions, the signaling pathways involved in the …

Influenza A virus (IAV) infection of epithelial cells activates NF-κB transcription factors via the
canonical NF-κB signaling pathway, which modulates both the antiviral immune response …

This invention discloses methods and compositions for modulating immune responses,
which involve particulate delivery of agents to immune cells, wherein the agents com prise …

Increasing evidence shows that many transcription factors execute important biologic
functions independent from their DNA-binding capacity. The NF-κB p65 (RELA) subunit is a …

The mechanisms that govern proteolytic maturation or complete destruction of the precursor
proteins p100 and p105 are fundamental to homeostasis and activation of NF-κB; however …

Histone deacetylase (HDAC) inhibitors are emerging as a promising new class of cancer
therapeutic agents. HDAC inhibitors relieve the deacetylation of histone proteins. However …

Tissue microenvironment functions as an important determinant of the inflammatory
response elicited by the resident cells. Yet, the underlying molecular mechanisms remain …

HIV modulates plasmacytoid dendritic cell (pDC) activation via Toll-like receptor 7, inducing
type I IFN and inflammatory cytokines. Simultaneously, pDCs up-regulate the expression of …