Endometrial carcinoma (EC) is a common female cancer, treated mainly by surgery and
adjuvant radiotherapy. Relapse following treatment is associated with increased risk of …

Interleukin-12 (IL-12) has emerged as an attractive cytokine for cancer therapy because it
has direct anti-cancer effects and additionally plays a critical role in enhancing checkpoint …

A role for the p52 NF-κB subunit in tumorigenesis has been steadily emerging since its
discovery as a gene associated with chromosomal translocations in B-and T-cell …

NF-κB transmits signals from the cell surface to the nucleus. Signaling through cell surface
receptors to activate NF-κB and mitogen-activated protein kinases through adaptor …

Nuclear factor (NF)-κB is a major regulator of antiviral response. Viral pathogens exploit NF-
κB activation pathways to avoid cellular mechanisms that eliminate the infection. Canonical …

The NF-κB family of transcription factors is vital to all aspects of immune function and
regulation in both the hemopoietic and stromal compartments of immune environments …

CATERPILLER is a mammalian gene family with signature NBD and LRR domains. Several
members of this family are positive regulators of inflammatory responses. Others, however …

IκB kinase (IKK), discovered as the major activator of NF-κB, plays additional roles in
signaling. By using mouse embryo fibroblasts (MEFs) lacking both the α and β subunits of …

ABSTRACT NF-κB is an important transcriptional factor that is involved in multiple cellular
responses, such as inflammation and antiapoptosis. IκB kinase α (IKKα) and IKKβ, which are …

The human herpes virus 8 (HHV8)-encoded viral FLICE inhibitory protein (vFLIP), also
known as K13, is known to activate the NF-κB pathway, a property not shared by other …