100 years of Mycobacterium bovis bacille Calmette-Guérin

C Lange, P Aaby, MA Behr, PR Donald… - The Lancet Infectious …, 2022 - thelancet.com
Summary Mycobacterium bovis bacille Calmette-Guérin (BCG), an experimental vaccine
designed to protect cattle from bovine tuberculosis, was administered for the first time to a …

Of tuberculosis and non-tuberculous mycobacterial infections–a comparative analysis of epidemiology, diagnosis and treatment

R Gopalaswamy, S Shanmugam, R Mondal… - Journal of biomedical …, 2020 - Springer
Pulmonary diseases due to mycobacteria cause significant morbidity and mortality to human
health. In addition to tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), recent …

[HTML][HTML] Could BCG vaccination induce protective trained immunity for SARS-CoV-2?

C Covián, A Retamal-Díaz, SM Bueno… - Frontiers in …, 2020 - frontiersin.org
Trained immunity is a type of non-specific memory-like immune response induced by some
pathogens and vaccines, such as BCG, which can confer antigen-independent protection …

Safety and immunogenicity of VPM1002 versus BCG in South African newborn babies: a randomised, phase 2 non-inferiority double-blind controlled trial

MF Cotton, SA Madhi, AK Luabeya… - The Lancet Infectious …, 2022 - thelancet.com
Background Tuberculosis is a major public health problem worldwide. Immunisation with
Mycobacterium bovis BCG vaccine is partially effective in infants, reducing the incidence of …

[HTML][HTML] Vaccine development against tuberculosis over the last 140 years: Failure as part of success

SHE Kaufmann - Frontiers in Microbiology, 2021 - frontiersin.org
The year 2020 was shaped by the COVID-19 pandemic which killed more people than any
other infectious disease in this particular year. At the same time, the development of highly …

Development and applications of viral vectored vaccines to combat zoonotic and emerging public health threats

SM Vrba, NM Kirk, ME Brisse, Y Liang, H Ly - Vaccines, 2020 - mdpi.com
Vaccination is arguably the most cost-effective preventative measure against infectious
diseases. While vaccines have been successfully developed against certain viruses (eg …

A century of BCG: Impact on tuberculosis control and beyond

A Ahmed, S Rakshit, V Adiga, M Dias… - Immunological …, 2021 - Wiley Online Library
BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …

VPM1002 as prophylaxis against severe respiratory tract infections including coronavirus disease 2019 in the elderly: a phase 3 randomized, double-blind, placebo …

AM Blossey, S Brückner, M May… - Clinical Infectious …, 2023 - academic.oup.com
Abstract Background Bacille Calmette-Guérin (BCG) vaccination can potentially reduce the
rate of respiratory infections in vulnerable populations. This study evaluates the safety and …

Recent developments, challenges and future prospects in advanced drug delivery systems in the management of tuberculosis

N Verma, V Arora, R Awasthi, Y Chan, NK Jha… - Journal of Drug Delivery …, 2022 - Elsevier
Tuberculosis (TB) is reported as one of the most prevailing life-threatening health problems,
affecting almost one third of the population globally. It is one of a major reason of death with …

[HTML][HTML] Tuberculosis: The success tale of less explored dormant Mycobacterium tuberculosis

A Verma, A Ghoshal, VP Dwivedi… - Frontiers in Cellular and …, 2022 - frontiersin.org
Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that predominantly affects
the alveolar macrophages in the respiratory tract. Upon infection, the activation of TLR2 and …