Brucella spp. are facultative intracellular pathogens that have the ability to survive and
multiply in professional and non-professional phagocytes, and cause abortion in domestic …

Brucellosis is a zoonotic infection transmitted from animals to humans by the ingestion of
infected food products, direct contact with an infected animal or inhalation of aerosols. The …

The recently completed Caenorhabditis elegans genome sequence allows application of
high-throughput (HT) approaches for phenotypic analyses using RNA interference (RNAi) …

Complete sets of cloned protein-encoding open reading frames (ORFs), or ORFeomes, are
essential tools for large-scale proteomics and systems biology studies. Here we describe …

Several bacterial pathogens have TIR domain-containing proteins that contribute to their
pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have …

Innate immunity recognizes bacterial molecules bearing pathogen-associated molecular
patterns to launch inflammatory responses leading to the activation of adaptive immunity …

Predicting the behavior of living organisms is an enormous challenge given their vast
complexity. Efforts to model biological systems require large datasets generated by physical …

Background The brucellae are facultative intracellular bacteria that cause brucellosis, one of
the major neglected zoonoses. In endemic areas, vaccination is the only effective way to …

Bacteria of the Brucella genus are facultative intracellular class III pathogens. These bacteria
are able to control the intracellular trafficking of their vacuole, presumably by the use of yet …

Background The two-component BvrR/BvrS system is essential for Brucella abortus
virulence. It was shown previously that its dysfunction alters the expression of some major …